CELA3B

GENE INFORMATION

? »

Gene name

CELA3B (HGNC Symbol)

Synonyms

CBPP, ELA3B

Description

chymotrypsin-like elastase family, member 3B (HGNC Symbol)

Entrez gene summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]

Chromosome

1 (Chromosome progress)

Cytoband

p36.12

Chromosome location (bp)

22303514 - 22325135

Ensembl

ENSG00000219073 (version 73.37)

Entrez gene

23436

UniProt

P08861 (UniProt - Evidence at protein level)

neXtProt

NX_P08861

Antibodypedia

CELA3B antibodies
 

PROTEIN VIEW

? »
 
 
 
CELA3B-001
 
CELA3B-002
 
CELA3B-004
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CELA3B-001 ENSP00000338369
ENST00000337107
P08861
Show all »
Show » Show » 270 29.3 Yes 0
CELA3B-002 ENSP00000363798
ENST00000374666
P08861
Show all »
Show » Show » 164 17.4 No 0
CELA3B-004 ENSP00000383135
ENST00000400277
P08861
Show all »
Show » Show » 180 19.5 No 0