HEPN1

GENERAL INFORMATION

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Gene name

HEPN1

Gene description

Hepatocellular carcinoma, down-regulated 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at transcript level

Protein localization

Most normal tissues showed weak to moderate cytoplasmic staining. Additional membranous positivity was observed in ciliated cells while hepatocytes displayed additional nuclear immunoreactivity. Lung, parathyroid, renal glomeruli, decidual cells, smooth muscle and the lymphoid tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA063054
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression



GENE INFORMATION

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Gene name

HEPN1

Synonyms

Description

Hepatocellular carcinoma, down-regulated 1 (HGNC Symbol)

Entrez gene summary

This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354). [provided by RefSeq, Aug 2011]

Chromosome

11

Cytoband

q24.2

Chromosome location (bp)

124919244 - 124920677

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000221932 (version 78.38)

Entrez gene

641654

UniProt

Q6WQI6 (UniProt - Uncertain)

neXtProt

NX_Q6WQI6

Antibodypedia

HEPN1 antibodies


PROTEIN BROWSER

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ENST00000408930
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HEPN1-001 ENSP00000386143
ENST00000408930
Q6WQI6
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