PSMB11

GENE INFORMATION

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Gene name

PSMB11 (HGNC Symbol)

Synonyms

beta5t

Description

proteasome (prosome, macropain) subunit, beta type, 11 (HGNC Symbol)

Entrez gene summary

Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

23511376 - 23513269

Ensembl

ENSG00000222028 (version 73.37)

Entrez gene

122706

UniProt

A5LHX3 (UniProt - Evidence at transcript level)

neXtProt

NX_A5LHX3

Antibodypedia

PSMB11 antibodies
 

PROTEIN VIEW

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PSMB11-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMB11-001 ENSP00000386212
ENST00000408907
A5LHX3
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