The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
A majority of cancer tissues showed moderate to strong membranous and/or cytoplasmic positivity.
Colorectal, ovarian, endometrial, testicular, breast, urothelial, pancreatic and liver cancers displayed moderate to strong membranous staining. Malignant lymphomas exhibited moderate to strong cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.
Most malignant tissues displayed weak to moderate cytoplasmic staining. Several cases of renal cancer along with a few cases of colorectal, cervical and pancreatic cancers exhibited strong positivity. Several cases of malignant lymphomas, testis and lung cancer were negative.
Malignant tissues displayed moderate cytoplasmic and/or membranous positivity. Strong staining was observed in a few colorectal cancers. Several cases of malignant gliomas, lymphomas, prostate and renal cancers were negative.
Validation
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for at least one of the genes whereas any of the other genes has no available gene/protein characterization data or is contradicted by gene/protein
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for at least one of the genes whereas any of the other genes has no available gene/protein characterization data or is contradicted by gene/protein
The multi-targeting antibody yielding a staining pattern partly consistent with limited gene/protein characterization data or there is no available gene/protein characterization data for all or at least one of the genes
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for at least one of the genes whereas any of the other genes has no available gene/protein characterization data or is contradicted by gene/protein
