ADRA2B

GENE INFORMATION

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Gene name

ADRA2B (HGNC Symbol)

Synonyms

ADRA2L1, ADRA2RL1, ADRARL1

Description

adrenoceptor alpha 2B (HGNC Symbol)

Entrez gene summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. [provided by RefSeq, Aug 2011]

Chromosome

2 (Chromosome progress)

Cytoband

q11.1

Chromosome location (bp)

96778707 - 96781984

Ensembl

ENSG00000222040 (version 73.37)

Entrez gene

151

UniProt

P18089 (UniProt - Evidence at protein level)

neXtProt

NX_P18089

Antibodypedia

ADRA2B antibodies
 

PROTEIN VIEW

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ADRA2B-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADRA2B-001 ENSP00000387281
ENST00000409345
P18089
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