DHFR

CANCER ATLAS

? »

Gene description

Dihydrofolate reductase

Protein class

Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level
 
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY

? »
 
HPA051465
 
 
CAB037129
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 
 

Staining summary

Most malignancies showed weak to moderate cytoplasmic staining. Malignant lymphomas, colorectal and testicular cancers as well as several cases of malignant gliomas, urothelial, breast and gastric cancers were negative.
 

Level of antibody staining/expression





High
Medium
Low
Not detected