TNF

GENE INFORMATION

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Gene name

TNF (HGNC Symbol)

Synonyms

DIF, TNF-alpha, TNFA, TNFSF2

Description

tumor necrosis factor (HGNC Symbol)

Entrez gene summary

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.33

Chromosome location (bp)

31543344 - 31546113

Ensembl

ENSG00000232810 (version 73.37)

Entrez gene

7124

UniProt

P01375 (UniProt - Evidence at protein level)

neXtProt

NX_P01375

Antibodypedia

TNF antibodies
 

PROTEIN VIEW

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TNF-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNF-001 ENSP00000398698
ENST00000449264
P01375
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