TLR9

GENE INFORMATION

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Gene name

TLR9 (HGNC Symbol)

Synonyms

CD289

Description

toll-like receptor 9 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p21.2

Chromosome location (bp)

52255096 - 52273183

Ensembl

ENSG00000239732 (version 73.37)

Entrez gene

54106

UniProt

Q9NR96 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NR96

Antibodypedia

TLR9 antibodies
 

PROTEIN VIEW

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TLR9-001
 
TLR9-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TLR9-001 ENSP00000353874
ENST00000360658
Q9NR96
Show all »
Show » Show » 1032 115.9 Yes 1
TLR9-201 ENSP00000471046
ENST00000597542
Q9NR96
Show all »
Show » Show » 1056 118.7 No 1