PSMB9

GENE INFORMATION

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Gene name

PSMB9 (HGNC Symbol)

Synonyms

beta1i, LMP2, PSMB6i, RING12

Description

proteasome (prosome, macropain) subunit, beta type, 9 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]

Chromosome

6 (Chromosome progress)

Cytoband

p21.32

Chromosome location (bp)

32811913 - 32827362

Ensembl

ENSG00000240065 (version 73.37)

Entrez gene

5698

UniProt

P28065 (UniProt - Evidence at protein level)

neXtProt

NX_P28065

Antibodypedia

PSMB9 antibodies
 

PROTEIN VIEW

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PSMB9-001
 
PSMB9-005
 
PSMB9-006
 
PSMB9-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMB9-001 ENSP00000363993
ENST00000374859
P28065
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Show » Show » 219 23.3 No 0
PSMB9-005 ENSP00000378739
ENST00000395330
A2ACR1
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Show » 196 21 No 0
PSMB9-006 ENSP00000394363
ENST00000414474
A2ACR0
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Show » 131 13.9 No 0
PSMB9-202 ENSP00000394773
ENST00000453265
B4DZW2
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Show » 154 16.4 No 0