HLA-DOB

GENE INFORMATION

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Gene name

HLA-DOB

Synonyms

Description

major histocompatibility complex, class II, DO beta (HGNC Symbol)

Entrez gene summary

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.32

Chromosome location (bp)

32780540 - 32784825

Ensembl

ENSG00000241106 (version 73.37)

Entrez gene

3112

UniProt

P13765 (UniProt - Evidence at protein level)

neXtProt

NX_P13765

Antibodypedia

HLA-DOB antibodies
 

PROTEIN VIEW

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HLA-DOB-001
 
HLA-DOB-003
 
HLA-DOB-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DOB-001 ENSP00000390020
ENST00000438763
P13765
Show all »
Show » Show » 273 30.8 Yes 1
HLA-DOB-003 ENSP00000436618
ENST00000488325
E9PI00
Show all »
38 4.2 Yes 0
HLA-DOB-004 ENSP00000394860
ENST00000447394
Show » 182 20.7 No 0