HOGA1

GENE INFORMATION

? »

Gene name

HOGA1 (HGNC Symbol)

Synonyms

C10orf65, DHDPS2, DHDPSL, FLJ37472, NPL2

Description

4-hydroxy-2-oxoglutarate aldolase 1 (HGNC Symbol)

Entrez gene summary

The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]

Chromosome

10 (Chromosome progress)

Cytoband

q24.2

Chromosome location (bp)

99344080 - 99372559

Ensembl

ENSG00000241935 (version 73.37)

Entrez gene

112817

UniProt

Q86XE5 (UniProt - Evidence at protein level)

neXtProt

NX_Q86XE5

Antibodypedia

HOGA1 antibodies
 

PROTEIN VIEW

? »
 
 
 
HOGA1-001
 
HOGA1-003
 
HOGA1-004
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HOGA1-001 ENSP00000359681
ENST00000370647
Q86XE5
Show all »
Show » Show » 164 18 No 0
HOGA1-003 ENSP00000359680
ENST00000370646
Q86XE5
Show all »
Show » Show » 327 35.2 No 0
HOGA1-004 ENSP00000359676
ENST00000370642
Show » Show » 85 8.9 No 0