STRC

GENERAL INFORMATION

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Gene name

STRC

Gene description

Stereocilin

Protein class

Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (testis)
GTEx:Group enriched (cerebellum, testis)

Protein evidence

Evidence at protein level

Protein localization

Normal tissues displayed weak to moderate cytoplasmic positivity. Glandular epithelia exhibited additional distinct membranous positivity. Prostate, endothelial cells and megakaryocytes showed strong immunoreactivity. Hepatocytes and squamous epithelia were mainly negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA015731
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, testis)

Organ

Expression



GENE INFORMATION

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Gene name

STRC (HGNC Symbol)

Synonyms

DFNB16

Description

Stereocilin (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q15.3

Chromosome location (bp)

43599398 - 43618800

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000242866 (version 78.38)

Entrez gene

161497

UniProt

Q7RTU9 (UniProt - Evidence at transcript level)

neXtProt

NX_Q7RTU9

Antibodypedia

STRC antibodies


PROTEIN BROWSER

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ENST00000432436
 
ENST00000450892
 
ENST00000541030
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STRC-001 ENSP00000401513
ENST00000450892
Q7RTU9
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Show » Show » 1775 193 Yes 0
STRC-005 ENSP00000407303
ENST00000432436
H7C2Q6
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Show » 663 70.9 No 0
STRC-201 ENSP00000440413
ENST00000541030
F5GXA4
Show all »
Show » 1002 110.7 No 0