CFB

GENE INFORMATION

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Gene name

CFB (HGNC Symbol)

Synonyms

BF, BFD, H2-Bf

Description

complement factor B (HGNC Symbol)

Entrez gene summary

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.33

Chromosome location (bp)

31895475 - 31919861

Ensembl

ENSG00000243649 (version 73.37)

Entrez gene

629

UniProt

P00751 (UniProt - Evidence at protein level)

neXtProt

NX_P00751

Antibodypedia

CFB antibodies
 

PROTEIN VIEW

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CFB-001
 
CFB-002
 
CFB-005
 
CFB-012
 
CFB-013
 
CFB-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CFB-001 ENSP00000416561
ENST00000425368
P00751
Show all »
Show » Show » 764 85.5 Yes 0
CFB-002 ENSP00000420090
ENST00000475617
C9JRT3
Show all »
Show » 144 16.1 Yes 0
CFB-005 ENSP00000417793
ENST00000460718
F8WBL9
Show all »
Show » 86 9.6 No 0
CFB-012 ENSP00000418833
ENST00000498317
Show » 68 7.3 No 0
CFB-013 ENSP00000419887
ENST00000483004
Show » 305 34.6 No 0
CFB-201 ENSP00000451848
ENST00000556679
B4E1Z4
Show all »
Show » Show » 1266 140.9 Yes 0