C4A

GENE INFORMATION

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Gene name

C4A (HGNC Symbol)

Synonyms

C4, C4A2, C4A3, C4A4, C4A6, C4B, C4S, CO4, CPAMD2, RG

Description

complement component 4A (Rodgers blood group) (HGNC Symbol)

Entrez gene summary

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

6 (Chromosome progress)

Cytoband

p21.33

Chromosome location (bp)

31949801 - 31970458

Ensembl

ENSG00000244731 (version 73.37)

Entrez gene

720

UniProt

P0C0L4 (UniProt - Evidence at protein level)

neXtProt

NX_P0C0L4

Antibodypedia

C4A antibodies
 

PROTEIN VIEW

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C4A-001
 
C4A-013
 
C4A-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C4A-001 ENSP00000396688
ENST00000428956
P0C0L4
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Show » Show » 1744 192.8 Yes 0
C4A-013 ENSP00000420212
ENST00000498271
P0C0L4
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Show » Show » 1698 187.7 Yes 0
C4A-204 ENSP00000446217
ENST00000537134
F5H2J9
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Show » 270 30.4 No 0