CDK11B

GENE INFORMATION

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Gene name

CDK11B (HGNC Symbol)

Synonyms

CDC2L1, CDK11-p110, CDK11-p46, CDK11-p58

Description

Cyclin-dependent kinase 11B (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.33

Chromosome location (bp)

1570603 - 1590473

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000248333 (version 75.37)

Entrez gene

728642

UniProt

neXtProt

Antibodypedia

CDK11B antibodies
 

PROTEIN VIEW

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CDK11B-001
 
CDK11B-002
 
CDK11B-201
 
CDK11B-202
 
CDK11B-203
 
CDK11B-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK11B-001 ENSP00000344418
ENST00000341028
Q5QPQ9
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Show » 75 9.2 No 0
CDK11B-002 ENSP00000463404
ENST00000513088
A4VCI5
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Show » Show » 618 70.8 No 0
CDK11B-201 ENSP00000463200
ENST00000317673
J3QKR5
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Show » Show » 783 90.2 No 0
CDK11B-202 ENSP00000464016
ENST00000340677
J3QR29
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Show » Show » 772 89.4 No 0
CDK11B-203 ENSP00000463048
ENST00000341832
J3KTL7
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Show » Show » 738 85.2 No 0
CDK11B-204 ENSP00000464036
ENST00000407249
J3QR44
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Show » Show » 785 90.6 No 0