PDCD6

GENERAL INFORMATION

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Gene name

PDCD6

Gene description

Programmed cell death 6

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PDCD6 (HGNC Symbol)

Synonyms

ALG-2, PEF1B

Description

Programmed cell death 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

271621 - 353856

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000249915 (version 78.38)

Entrez gene

10016

UniProt

O75340 (UniProt - Evidence at protein level)

neXtProt

NX_O75340

Antibodypedia

PDCD6 antibodies


PROTEIN BROWSER

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ENST00000264933
 
ENST00000505221
 
ENST00000507473
 
ENST00000507528
 
ENST00000509581
 
ENST00000614778
 
ENST00000618970
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDCD6-001 ENSP00000264933
ENST00000264933
O75340
Show all »
Show » Show » 191 21.9 No 0
PDCD6-006 ENSP00000422691
ENST00000509581
Q86W51
Show all »
Show » Show » 55 5.7 No 0
PDCD6-008 ENSP00000423815
ENST00000507528
O75340
Show all »
Show » Show » 189 21.7 No 0
PDCD6-011 ENSP00000422085
ENST00000505221
O75340
Show all »
Show » Show » 69 7.3 No 0
PDCD6-012 ENSP00000425370
ENST00000507473
H0Y9X3
Show all »
Show » Show » 104 12.2 No 0
PDCD6-201 ENSP00000485024
ENST00000614778
A0A024QZ42
Show all »
Show » Show » 121 14.5 No 0
PDCD6-202 ENSP00000482332
ENST00000618970
Q86W51
Show all »
Show » Show » 123 14 No 0