SEPP1

GENE INFORMATION

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Gene name

SEPP1 (HGNC Symbol)

Synonyms

SeP

Description

selenoprotein P, plasma, 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

p12

Chromosome location (bp)

42799982 - 42887494

Ensembl

ENSG00000250722 (version 73.37)

Entrez gene

6414

UniProt

P49908 (UniProt - Evidence at protein level)

neXtProt

NX_P49908

Antibodypedia

SEPP1 antibodies
 

PROTEIN VIEW

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SEPP1-001
 
SEPP1-002
 
SEPP1-004
 
SEPP1-005
 
SEPP1-006
 
SEPP1-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SEPP1-001 ENSP00000420939
ENST00000514985
P49908
Show all »
Show » Show » 381 43.2 Yes 0
SEPP1-002 ENSP00000427671
ENST00000511224
P49908
Show all »
Show » Show » 381 43.2 Yes 0
SEPP1-004 ENSP00000425915
ENST00000506577
P49908
Show all »
Show » Show » 381 43.2 Yes 0
SEPP1-005 ENSP00000421626
ENST00000514218
Show » 310 35.2 Yes 0
SEPP1-006 ENSP00000427414
ENST00000510965
Show » 209 23.7 Yes 0
SEPP1-012 ENSP00000473340
ENST00000507920
Show » Show » 171 19.4 Yes 3