INS

GENE INFORMATION

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Gene name

INS

Synonyms

Description

insulin (HGNC Symbol)

Entrez gene summary

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Chromosome

11 (Chromosome progress)

Cytoband

p15.5

Chromosome location (bp)

2181009 - 2182571

Ensembl

ENSG00000254647 (version 73.37)

Entrez gene

3630

UniProt

P01308 (UniProt - Evidence at protein level)

neXtProt

NX_P01308

Antibodypedia

INS antibodies
 

PROTEIN VIEW

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INS-001
 
INS-002
 
INS-003
 
INS-005
 
INS-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INS-001 ENSP00000370731
ENST00000381330
P01308
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Show » Show » 110 12 Yes 0
INS-002 ENSP00000250971
ENST00000250971
P01308
Show all »
Show » Show » 110 12 Yes 0
INS-003 ENSP00000380432
ENST00000397262
P01308
Show all »
Show » Show » 110 12 Yes 0
INS-005 ENSP00000408400
ENST00000421783
C9JNR5
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Show » Show » 92 10.6 Yes 0
INS-006 ENSP00000424008
ENST00000512523
A6XGL2
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Show » Show » 98 11 Yes 0