CHMP1B

GENERAL INFORMATION

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Gene name

CHMP1B

Gene description

Charged multivesicular body protein 1B

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression with a granular pattern that in some tissues is combined with expression in membrane and nuclei.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA061997 , HPA062896
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CHMP1B (HGNC Symbol)

Synonyms

C18orf2, CHMP1.5, Vps46B

Description

Charged multivesicular body protein 1B (HGNC Symbol)

Entrez gene summary

CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Chromosome

18

Cytoband

p11.21

Chromosome location (bp)

11851396 - 11854449

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000255112 (version 78.38)

Entrez gene

57132

UniProt

Q7LBR1 (UniProt - Evidence at protein level)

neXtProt

NX_Q7LBR1

Antibodypedia

CHMP1B antibodies


PROTEIN BROWSER

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ENST00000526991
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHMP1B-001 ENSP00000432279
ENST00000526991
Q7LBR1
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