CYP2A6

GENE INFORMATION

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Gene name

CYP2A6 (HGNC Symbol)

Synonyms

CPA6, CYP2A, CYP2A3

Description

cytochrome P450, family 2, subfamily A, polypeptide 6 (HGNC Symbol)

Entrez gene summary

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

41349443 - 41356352

Ensembl

ENSG00000255974 (version 73.37)

Entrez gene

1548

UniProt

P11509 (UniProt - Evidence at protein level)

neXtProt

NX_P11509

Antibodypedia

CYP2A6 antibodies
 

PROTEIN VIEW

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CYP2A6-001
 
CYP2A6-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2A6-001 ENSP00000301141
ENST00000301141
P11509
Show all »
Show » Show » 494 56.5 Yes 0
CYP2A6-002 ENSP00000472905
ENST00000600495
M0R2Z4
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Show » Show » 65 7.3 Yes 0