TAS2R38

GENE INFORMATION

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Gene name

TAS2R38 (HGNC Symbol)

Synonyms

PTC, T2R61

Description

taste receptor, type 2, member 38 (HGNC Symbol)

Entrez gene summary

This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]

Chromosome

7 (Chromosome progress)

Cytoband

q34

Chromosome location (bp)

141672431 - 141673573

Ensembl

ENSG00000257138 (version 73.37)

Entrez gene

5726

UniProt

P59533 (UniProt - Evidence at transcript level)

neXtProt

NX_P59533

Antibodypedia

TAS2R38 antibodies
 

PROTEIN VIEW

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TAS2R38-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TAS2R38-001 ENSP00000448219
ENST00000547270
P59533
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