GH1

GENE INFORMATION

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Gene name

GH1 (HGNC Symbol)

Synonyms

GH, GH-N, GHN, hGH-N

Description

growth hormone 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

61994560 - 61996179

Ensembl

ENSG00000259384 (version 73.37)

Entrez gene

2688

UniProt

P01241 (UniProt - Evidence at protein level)

neXtProt

NX_P01241

Antibodypedia

GH1 antibodies
 

PROTEIN VIEW

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GH1-001
 
GH1-003
 
GH1-004
 
GH1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GH1-001 ENSP00000312673
ENST00000323322
P01241
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Show » Show » 217 24.8 Yes 0
GH1-003 ENSP00000408486
ENST00000458650
P01241
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Show » Show » 202 23 Yes 0
GH1-004 ENSP00000343791
ENST00000351388
P01241
Show all »
Show » Show » 177 20.2 Yes 0
GH1-005 ENSP00000339278
ENST00000342364
B1A4G9
Show all »
Show » Show » 122 14 Yes 0