MRPL12

GENE INFORMATION

? »

Gene name

MRPL12 (HGNC Symbol)

Synonyms

MRPL7, MRPL7/L12, RPML12

Description

mitochondrial ribosomal protein L12 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q25.3

Chromosome location (bp)

79670387 - 79674556

Ensembl

ENSG00000262814 (version 73.37)

Entrez gene

6182

UniProt

P52815 (UniProt - Evidence at protein level)

neXtProt

NX_P52815

Antibodypedia

MRPL12 antibodies
 

PROTEIN VIEW

? »
 
 
 
MRPL12-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL12-001 ENSP00000333837
ENST00000333676
P52815
Show all »
Show » Show » 198 21.3 No 0