STRADA

GENE INFORMATION

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Gene name

STRADA (HGNC Symbol)

Synonyms

LYK5, NY-BR-96, Stlk, STRAD

Description

STE20-related kinase adaptor alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

Chromosome

17 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

61780192 - 61819330

Ensembl

ENSG00000266173 (version 73.37)

Entrez gene

92335

UniProt

Q7RTN6 (UniProt - Evidence at protein level)

neXtProt

NX_Q7RTN6

Antibodypedia

STRADA antibodies
 

PROTEIN VIEW

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 « 
 
STRADA-001
 
STRADA-003
 
STRADA-004
 
STRADA-005
 
STRADA-006
 
STRADA-007
 
STRADA-009
 
STRADA-010
 
STRADA-011
 
STRADA-012
 
STRADA-013
 
STRADA-015
 
STRADA-016
 
STRADA-019
 
STRADA-020
 
STRADA-022
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STRADA-001 ENSP00000336655
ENST00000336174
Q7RTN6
Show all »
Show » Show » 431 48.4 No 0
STRADA-003 ENSP00000376677
ENST00000392950
Q7RTN6
Show all »
Show » Show » 348 38.6 No 0
STRADA-004 ENSP00000398841
ENST00000447001
Q7RTN6
Show all »
Show » Show » 299 33.3 No 0
STRADA-005 ENSP00000245865
ENST00000245865
Q86YC8
Show all »
Show » Show » 234 26.1 No 0
STRADA-006 ENSP00000462922
ENST00000582137
Q7RTN6
Show all »
Show » Show » 314 34.6 No 0
STRADA-007 ENSP00000365000
ENST00000375840
Q7RTN6
Show all »
Show » Show » 373 41.7 No 0
STRADA-009 ENSP00000463203
ENST00000580338
J3QKR7
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Show » 78 8.8 No 0
STRADA-010 ENSP00000463238
ENST00000580288
J3QKU4
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45 5.3 No 0
STRADA-011 ENSP00000462384
ENST00000579549
J3KSA2
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72 7.9 No 0
STRADA-012 ENSP00000462496
ENST00000584110
10 1 No 0
STRADA-013 ENSP00000464139
ENST00000582030
J3QRC1
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50 5.6 No 0
STRADA-015 ENSP00000464085
ENST00000581243
J3QR78
Show all »
40 4.7 No 0
STRADA-016 ENSP00000462530
ENST00000579340
J3KSK5
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Show » 173 19.6 No 0
STRADA-019 ENSP00000463872
ENST00000578801
J3QQS3
Show all »
Show » 131 14.9 No 0
STRADA-020 ENSP00000464547
ENST00000578008
J3QS66
Show all »
Show » 167 18.6 No 0
STRADA-022 ENSP00000464213
ENST00000582026
Show » 55 6.2 No 0