The Human Protein Atlas portal is a publicly available database with millions of high-resolution images showing the spatial distribution of proteins in 44 different normal human tissues and 20 different cancer types, as well as 46 different human cell lines. The data is released together with application-specific validation performed for each antibody, including immunohistochemisty, Western blot analysis and, for a large fraction, a protein array assay and immunofluorescent based confocal microscopy. The database has been developed in a gene-centric manner with the inclusion of all human genes predicted from genome efforts. Search functionalities allow for complex queries regarding protein expression profiles, protein classes and chromosome location.
Uhlen et al (2010). Towards a knowledge-based Human Protein Atlas. Nat Biotechnol. 28(12):1248-50. PubMed: 21139605 DOI: 10.1038/nbt1210-1248
Berglund et al (2008). A gene-centric Human Protein Atlas for expression profiles based on antibodies. Mol Cell Proteomics. 7(10):2019-27. PubMed: 18669619 DOI: 10.1074/mcp.R800013-MCP200
Uhlen et al (2005). A human protein atlas for normal and cancer tissues based on antibody proteomics. Mol Cell Proteomics. 4(12):1920-1932. PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200
Ponten et al (2008). The Human Protein Atlas--a tool for pathology. J Pathology. 216(4):387-93. PubMed: 18853439 DOI: 10.1002/path.2440
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.