PROTEIN CLASSES

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Main classes

Protein class

No of genes

No of genes with antibodies

Source

Kinases 504 469 UniProt
CD markers 379 320 UniProt
Blood group antigen proteins 31 25 UniProt
Transporters 933 782 TCDB
Ribosomal proteins 152 134 UniProt
Peptidases 528 473 UniProt/Merops
GPCRs excl olfactory receptors 393 279 UniProt
Transcription factors 1364 1094 DBD
Enzymes 2889 2642 ENZYME
SH2-domain containing proteins 110 101 InterPro
SH3-domain containing proteins 218 207 InterPro
Voltage-gated ion channels 131 105 IUPHAR-DB
Membrane proteins predicted by MDM 5558 4401 MDM


Project related classes

Protein class

No of genes

No of genes with antibodies

Source

Candidate cancer biomarkers 1052 939 Plasma Proteome Institute
Plasma proteins 678 597 Plasma Proteome Institute
Candidate cardiovascular disease genes 162 143 Plasma Proteome Institute
Mutated genes in cancer 380 334 Cancer genome project
Mapped to UniProt SWISS-PROT 19064 16220 UniProt
UniProt - Evidence at protein level 13421 11920 UniProt
UniProt - Evidence at transcript level 5340 4108 UniProt
UniProt - Inferred from homology 122 77 UniProt
UniProt - Predicted 78 47 UniProt
UniProt - Uncertain 121 81 UniProt


Kinases

Protein class

No of genes

No of genes with antibodies

Source

AGC Ser/Thr protein kinases 57 54 UniProt
CAMK Ser/Thr protein kinases 74 67 UniProt
CK1 Ser/Thr protein kinases 12 11 UniProt
CMGC Ser/Thr protein kinases 61 57 UniProt
NEK Ser/Thr protein kinases 11 11 UniProt
RGC receptor guanylate cyclase kinases 5 4 UniProt
STE Ser/Thr protein kinases 55 54 UniProt
TKL Ser/Thr protein kinases 34 30 UniProt
Tyr protein kinases 90 82 UniProt
Atypical kinases 27 26 UniProt


Transporters

Protein class

No of genes

No of genes with antibodies

Source

Transporter channels and pores 244 196 TCDB
Electrochemical Potential-driven transporters 381 322 TCDB
Primary Active Transporters 123 114 TCDB
Transport Electron Carriers 10 8 TCDB
Accessory Factors Involved in Transport 43 39 TCDB


Peptidases

Protein class

No of genes

No of genes with antibodies

Source

Aspartic-type peptidases 17 17 UniProt/Merops
Cysteine-type peptidases 156 146 UniProt/Merops
Metallopeptidases 172 152 UniProt/Merops
Serine-type peptidases 163 139 UniProt/Merops
Threonine-type peptidases 20 19 UniProt/Merops


G-protein coupled receptors

Protein class

No of genes

No of genes with antibodies

Source

GPCRs excl olfactory receptors 393 279 UniProt
Adenosine and adenine nucleotide receptors 17 14 UniProt
Chemokines and chemotactic factors receptors 29 24 UniProt
Lysolipids receptors 14 12 UniProt
Odorant/olfactory and gustatory receptors 378 109 UniProt
Opsins 10 3 UniProt
Serotonin receptors 12 11 UniProt
Family 2 (B) receptors 48 40 UniProt
Family T2R receptors (taste receptor GPCRs) 23 6 UniProt
Family fz/smo receptors 11 9 UniProt


Enzymes

Protein class

No of genes

No of genes with antibodies

Source

Oxidoreductases 381 345 ENZYME
Transferases 1190 1082 ENZYME
Hydrolases 1018 936 ENZYME
Lyases 122 117 ENZYME
Isomerase 100 90 ENZYME
Ligase 131 122 ENZYME


Voltage-gated ion channels

Protein class

No of genes

No of genes with antibodies

Source

Calcium-Activated Potassium Channels 6 6 IUPHAR-DB
CatSper and Two-Pore Channels 4 4 IUPHAR-DB
Cyclic Nucleotide-Regulated Channels 9 3 IUPHAR-DB
Inwardly Rectifying Potassium Channels 15 13 IUPHAR-DB
Transient Receptor Potential Channels 24 20 IUPHAR-DB
Two-P Potassium Channels 14 9 IUPHAR-DB
Voltage-Gated Calcium Channels 10 7 IUPHAR-DB
Voltage-Gated Potassium Channels 40 35 IUPHAR-DB
Voltage-Gated Sodium Channels 9 8 IUPHAR-DB


Potential transmembrane proteins

Protein class

No of genes

No of genes with antibodies

Source

Membrane proteins predicted by MDM 5558 4401 MDM
MEMSAT3 predicted membrane proteins 7339 5911 MEMSAT3
MEMSAT-SVM predicted membrane proteins 6381 5102 MEMSAT-SVM
Phobius predicted membrane proteins 5909 4691 Phobius
SCAMPI predicted membrane proteins 6525 5267 SCAMPI
SPOCTOPUS predicted membrane proteins 7812 6375 SPOCTOPUS
THUMBUP predicted membrane proteins 7272 5848 THUMBUP
TMHMM predicted membrane proteins 5638 4441 TMHMM
GPCRHMM predicted membrane proteins 821 432 GPCRHMM
1TM proteins predicted by MDM 3336 2838 MDM
2TM proteins predicted by MDM 1031 868 MDM
3TM proteins predicted by MDM 597 490 MDM
4TM proteins predicted by MDM 589 479 MDM
5TM proteins predicted by MDM 332 273 MDM
6TM proteins predicted by MDM 351 292 MDM
7TM proteins predicted by MDM 957 558 MDM
8TM proteins predicted by MDM 181 150 MDM
9TM proteins predicted by MDM 139 118 MDM
>9TM proteins predicted by MDM 488 425 MDM


Mapped to UniProt SWISS-PROT

Protein class

No of genes

No of genes with antibodies

Source

UniProt - Evidence at protein level 13421 11920 UniProt
UniProt - Evidence at transcript level 5340 4108 UniProt
UniProt - Inferred from homology 122 77 UniProt
UniProt - Predicted 78 47 UniProt
UniProt - Uncertain 121 81 UniProt