The Human Protein Atlas

PROTEIN CLASSES

Main classes
Protein class	No of genes	No of genes with antibodies	Source
Kinases	504	418	UniProt
CD markers	380	282	UniProt
Blood group antigen proteins	30	20	UniProt
Transporters	528	370	TCDB
Ribosomal proteins	153	66	UniProt
Peptidases	505	384	UniProt/Merops
GPCRs excl olfactory receptors	390	217	UniProt
Transcription factors	1352	786	DBD
Enzymes	2759	2056	ENZYME
SH2-domain containing proteins	109	91	InterPro
SH3-domain containing proteins	208	172	InterPro
Voltage-gated ion channels	132	79	IUPHAR-DB
Membrane proteins predicted by MDM	5502	3249	MDM

Project related classes
Protein class	No of genes	No of genes with antibodies	Source
Candidate cancer biomarkers	1051	867	Plasma Proteome Institute
Plasma proteins	673	527	Plasma Proteome Institute
Candidate cardiovascular disease genes	162	132	Plasma Proteome Institute
Mutated genes in cancer	379	282	Cancer genome project
Mapped to UniProt SWISS-PROT	18926	12032	UniProt
UniProt - Evidence at protein level	13123	9168	UniProt
UniProt - Evidence at transcript level	5559	2801	UniProt
UniProt - Inferred from homology	122	22	UniProt
UniProt - Predicted	62	11	UniProt
UniProt - Uncertain	185	69	UniProt

Kinases
Protein class	No of genes	No of genes with antibodies	Source
AGC Ser/Thr protein kinases	57	49	UniProt
CAMK Ser/Thr protein kinases	73	56	UniProt
CK1 Ser/Thr protein kinases	12	10	UniProt
CMGC Ser/Thr protein kinases	61	53	UniProt
NEK Ser/Thr protein kinases	11	9	UniProt
RGC receptor guanylate cyclase kinases	5	4	UniProt
STE Ser/Thr protein kinases	55	46	UniProt
TKL Ser/Thr protein kinases	34	29	UniProt
Tyr protein kinases	90	78	UniProt
Atypical kinases	26	23	UniProt

Transporters
Protein class	No of genes	No of genes with antibodies	Source
Transporter channels and pores	184	123	TCDB
Electrochemical Potential-driven transporters	162	112	TCDB
Primary Active Transporters	104	78	TCDB
Transport Electron Carriers	8	6	TCDB
Accessory Factors Involved in Transport	28	19	TCDB

G-protein coupled receptors
Protein class	No of genes	No of genes with antibodies	Source
GPCRs excl olfactory receptors	390	217	UniProt
Adenosine and adenine nucleotide receptors	17	12	UniProt
Chemokines and chemotactic factors receptors	29	21	UniProt
Lysolipids receptors	14	7	UniProt
Odorant/olfactory and gustatory receptors	374	20	UniProt
Opsins	10	3	UniProt
Serotonin receptors	12	8	UniProt
Family 2 (B) receptors	48	31	UniProt
Family T2R receptors (taste receptor GPCRs)	21	2	UniProt
Family fz/smo receptors	11	7	UniProt

Voltage-gated ion channels
Protein class	No of genes	No of genes with antibodies	Source
Calcium-Activated Potassium Channels	7	1	IUPHAR-DB
CatSper and Two-Pore Channels	4	3	IUPHAR-DB
Cyclic Nucleotide-Regulated Channels	9	2	IUPHAR-DB
Inwardly Rectifying Potassium Channels	15	10	IUPHAR-DB
Transient Receptor Potential Channels	24	16	IUPHAR-DB
Two-P Potassium Channels	14	6	IUPHAR-DB
Voltage-Gated Calcium Channels	10	6	IUPHAR-DB
Voltage-Gated Potassium Channels	40	28	IUPHAR-DB
Voltage-Gated Sodium Channels	9	7	IUPHAR-DB

Potential transmembrane proteins
Protein class	No of genes	No of genes with antibodies	Source
Membrane proteins predicted by MDM	5502	3249	MDM
MEMSAT3 predicted membrane proteins	7269	4370	MEMSAT3
MEMSAT-SVM predicted membrane proteins	6287	3777	MEMSAT-SVM
Phobius predicted membrane proteins	5802	3454	Phobius
SCAMPI predicted membrane proteins	6376	3848	SCAMPI
SPOCTOPUS predicted membrane proteins	7736	4771	SPOCTOPUS
THUMBUP predicted membrane proteins	7189	4323	THUMBUP
TMHMM predicted membrane proteins	5534	3273	TMHMM
GPCRHMM predicted membrane proteins	823	270	GPCRHMM
1TM proteins predicted by MDM	3201	2111	MDM
2TM proteins predicted by MDM	975	624	MDM
3TM proteins predicted by MDM	574	333	MDM
4TM proteins predicted by MDM	586	324	MDM
5TM proteins predicted by MDM	333	185	MDM
6TM proteins predicted by MDM	354	218	MDM
7TM proteins predicted by MDM	962	367	MDM
8TM proteins predicted by MDM	186	108	MDM
9TM proteins predicted by MDM	137	83	MDM
>9TM proteins predicted by MDM	488	310	MDM

Mapped to UniProt SWISS-PROT
Protein class	No of genes	No of genes with antibodies	Source
UniProt - Evidence at protein level	13123	9168	UniProt
UniProt - Evidence at transcript level	5559	2801	UniProt
UniProt - Inferred from homology	122	22	UniProt
UniProt - Predicted	62	11	UniProt
UniProt - Uncertain	185	69	UniProt

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.