The Human Protein Atlas

PROTEIN CLASSES

Main classes
Protein class	No of genes	No of genes with antibodies	Source
Kinases	503	445	UniProt
CD markers	379	312	UniProt
Blood group antigen proteins	29	21	UniProt
Transporters	889	698	TCDB
Ribosomal proteins	152	120	UniProt
Peptidases	513	441	UniProt/Merops
GPCRs excl olfactory receptors	392	251	UniProt
Transcription factors	1369	966	DBD
Enzymes	2843	2424	ENZYME
SH2-domain containing proteins	109	98	InterPro
SH3-domain containing proteins	215	196	InterPro
Voltage-gated ion channels	132	96	IUPHAR-DB
Membrane proteins predicted by MDM	5532	4034	MDM
Secreted proteins predicted by MDSP	4158	3223	MDSP

Project related classes
Protein class	No of genes	No of genes with antibodies	Source
Candidate cancer biomarkers	1053	911	Plasma Proteome Institute
Plasma proteins	677	574	Plasma Proteome Institute
Candidate cardiovascular disease genes	161	139	Plasma Proteome Institute
Mutated genes in cancer	379	313	Cancer genome project
Mapped to UniProt SWISS-PROT	19014	14788	UniProt
UniProt - Evidence at protein level	13465	11095	UniProt
UniProt - Evidence at transcript level	5278	3548	UniProt
UniProt - Inferred from homology	109	56	UniProt
UniProt - Predicted	62	30	UniProt
UniProt - Uncertain	134	79	UniProt

Kinases
Protein class	No of genes	No of genes with antibodies	Source
AGC Ser/Thr protein kinases	56	52	UniProt
CAMK Ser/Thr protein kinases	74	62	UniProt
CK1 Ser/Thr protein kinases	12	11	UniProt
CMGC Ser/Thr protein kinases	62	55	UniProt
NEK Ser/Thr protein kinases	11	11	UniProt
RGC receptor guanylate cyclase kinases	5	4	UniProt
STE Ser/Thr protein kinases	54	51	UniProt
TKL Ser/Thr protein kinases	34	28	UniProt
Tyr protein kinases	90	78	UniProt
Atypical kinases	26	24	UniProt

Transporters
Protein class	No of genes	No of genes with antibodies	Source
Transporter channels and pores	231	174	TCDB
Electrochemical Potential-driven transporters	377	300	TCDB
Primary Active Transporters	118	103	TCDB
Transport Electron Carriers	10	8	TCDB
Accessory Factors Involved in Transport	35	28	TCDB

G-protein coupled receptors
Protein class	No of genes	No of genes with antibodies	Source
GPCRs excl olfactory receptors	392	251	UniProt
Adenosine and adenine nucleotide receptors	17	14	UniProt
Chemokines and chemotactic factors receptors	29	22	UniProt
Lysolipids receptors	14	8	UniProt
Odorant/olfactory and gustatory receptors	378	71	UniProt
Opsins	10	3	UniProt
Serotonin receptors	12	10	UniProt
Family 2 (B) receptors	48	37	UniProt
Family T2R receptors (taste receptor GPCRs)	23	2	UniProt
Family fz/smo receptors	11	8	UniProt

Voltage-gated ion channels
Protein class	No of genes	No of genes with antibodies	Source
Calcium-Activated Potassium Channels	7	3	IUPHAR-DB
CatSper and Two-Pore Channels	4	4	IUPHAR-DB
Cyclic Nucleotide-Regulated Channels	9	3	IUPHAR-DB
Inwardly Rectifying Potassium Channels	15	11	IUPHAR-DB
Transient Receptor Potential Channels	24	19	IUPHAR-DB
Two-P Potassium Channels	14	8	IUPHAR-DB
Voltage-Gated Calcium Channels	10	7	IUPHAR-DB
Voltage-Gated Potassium Channels	40	33	IUPHAR-DB
Voltage-Gated Sodium Channels	9	8	IUPHAR-DB

Potential transmembrane proteins
Protein class	No of genes	No of genes with antibodies	Source
Membrane proteins predicted by MDM	5532	4034	MDM
MEMSAT3 predicted membrane proteins	7298	5402	MEMSAT3
MEMSAT-SVM predicted membrane proteins	6351	4673	MEMSAT-SVM
Phobius predicted membrane proteins	5861	4285	Phobius
SCAMPI predicted membrane proteins	6479	4810	SCAMPI
SPOCTOPUS predicted membrane proteins	7773	5865	SPOCTOPUS
THUMBUP predicted membrane proteins	7221	5345	THUMBUP
TMHMM predicted membrane proteins	5594	4051	TMHMM
GPCRHMM predicted membrane proteins	821	359	GPCRHMM
1TM proteins predicted by MDM	3305	2639	MDM
2TM proteins predicted by MDM	1018	793	MDM
3TM proteins predicted by MDM	590	435	MDM
4TM proteins predicted by MDM	581	415	MDM
5TM proteins predicted by MDM	336	245	MDM
6TM proteins predicted by MDM	349	263	MDM
7TM proteins predicted by MDM	959	479	MDM
8TM proteins predicted by MDM	181	134	MDM
9TM proteins predicted by MDM	136	103	MDM
>9TM proteins predicted by MDM	486	402	MDM

Potentially secreted proteins
Protein class	No of genes	No of genes with antibodies	Source
Secreted proteins predicted by MDSP	4158	3223	MDSP
SignalP predicted secreted proteins	3711	2871	SignalP
Phobius predicted secreted proteins	4655	3597	Phobius
SPOCTOPUS predicted secreted proteins	5297	4102	SPOCTOPUS

Mapped to UniProt SWISS-PROT
Protein class	No of genes	No of genes with antibodies	Source
UniProt - Evidence at protein level	13465	11095	UniProt
UniProt - Evidence at transcript level	5278	3548	UniProt
UniProt - Inferred from homology	109	56	UniProt
UniProt - Predicted	62	30	UniProt
UniProt - Uncertain	134	79	UniProt

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.