home

Release History

Protein Atlas version 6.0 - 2010.03.26

  • Sixth major release of the Human Protein Atlas with more than 11,200 antibodies and more than 9,100,000 images.
  • Membrane protein related protein classes have been added.
  • New membrane protein topology prediction methods have been added to the protein view.
  • The Two pore calcium channel protein 2 antibody (HPA0016561) has been omitted due to lack of membranous staining. An alternative antibody (HPA0027080), showing a membranous positivity, has been added to the Protein Atlas.
  • The Serine/threonine-protein kinase TNNI3K antibody (HPA013188) has been omitted due to lack of staining in heart muscle.
  • The Mitogen-activated protein kinase 12 antibody (HPA018841) has been omitted due to negative skeletal muscle. An alternative antibody (CAB025483), showing distinct staining in skeletal muscle, has been added to the protein atlas.
  • The Thyrotropin receptor Precursor antibody (CAB000473) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Serotonin antibody (CAB000074) has been omitted due to wrong ensg id.
  • The Neurotensin receptor type 1 antibody (HPA009132) has been omitted due to nuclear positivity and lack of staining in neurons.
  • The Neurexin-2-beta Precursor antibody (CAB012472) has been omitted due to ubiquitous granular cytoplasmic staining.
  • The Focal adhesion kinase 1 antibody (HPA001842) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Tumor necrosis factor receptor superfamily member 6 Precursor antibody (CAB000124) has been omitted due to weak staining. An alternative antibody (HPA027444), showing staining in inflammatory cells, has been added to the protein atlas.
  • The La-related protein 7 antibody (HPA017600) has been omitted due to cytoplasmic staining. Alternative antibodies (HPA026842 and HPA027930), showing mostly nuclear staining, have been added to the protein atlas.
  • The Tensin-3 antibody (HPA005547) has been omitted due to non-reliable protein expression patterns (IHC).
  • The ATP-sensitive inward rectifier potassium channel 8 (CAB009504) has been omitted due to lack of membranous staining. An alternative antibody (HPA0031066), showing a membranous positivity, has been added to the Protein Atlas.
  • The Pogo transposable element with KRAB domain antibody (HPA007838) has been omitted due to ubiquitous cytoplasmic and extracellular staining. An alternative antibody (HPA0031630) showing nuclear staining have been added to the protein atlas.
  • The Hepatocyte cell adhesion molecule Precursor antibody (HPA0017613) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Transketolase-like protein 1 antibody (HPA000505) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Laminin, alpha 2 antibody (HPA005537) has been omitted due to lack of staining in basement membranes.
  • The HPA000429 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA000523 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA001942 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA003249 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA003533 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA003535 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA003553 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA003721 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA004690 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA008331 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA009072 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA010930 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA011369 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA012133 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA013207 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA013788 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA014079 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA014207 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA014347 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA014904 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA014916 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA015796 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA017597 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA017657 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA018521 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA019064 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA019164 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA019546 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA020458 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA020854 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA020946 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA020953 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA021259 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA021268 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA021271 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA021324 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA021495 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA021642 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA021772 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA021782 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA022024 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA022247 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA022954 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA023061 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA023101 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA023105 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA023133 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA023538 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA023540 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA023931 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA024419 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA024454 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA024461 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA024799 antibody has been omitted due to target gene not found in Ensembl.
  • The HPA027245 antibody has been omitted due to target gene not found in Ensembl.
  • The CAB000074 antibody has been omitted due to target gene not found in Ensembl.
  • The CAB000017 antibody has been omitted due to target gene not found in Ensembl.
  • The CAB002774 antibody has been omitted due to target gene not found in Ensembl.
  • The CAB008668 antibody has been omitted due to target gene not found in Ensembl.
  • The CAB009395 antibody has been omitted due to target gene not found in Ensembl.
  • The CAB016176 antibody has been omitted due to target gene not found in Ensembl.

Protein Atlas version 5.0 - 2009.06.16

  • Fifth major release of the Human Protein Atlas with more than 8,800 antibodies and more than 7,300,000 images.
  • A new protein class group, Voltage-gated ion channels, has been added.
  • The Receptor tyrosine-protein kinase erbB-3 Precursor antibody (CAB000088) has been omitted due to lack of membrane positivity.
  • The Ubiquitin carboxyl-terminal hydrolase 26 antibody (HPA000424) has been omitted due to general positivity.
  • The Cleavage and polyadenylation specificity factor subunit 2 antibody (HPA000870) have been omitted due to cytoplasmic positivity. An alternative antibody (HPA024238), showing nuclear immunostaining pattern, has been added to the Protein Atlas.
  • The Paired box protein Pax-5 antibody (CAB001449) has been removed from the protein atlas since it has been discontinued by the commercial distributor. Two alternative antibodies (CAB026269 and CAB026869) have been added to the Protein Atlas.
  • The Serotonin N-acetyltransferase antibody (CAB001705) has been omitted due to general positivity.
  • The Monocyte differentiation antigen CD14 antibody (HPA002127) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Bcl-2-like protein 11 antibody (CAB002616) has been omitted due to nuclear positivity.
  • The AT-rich interactive domain-containing protein 5A antibody (HPA002860) has been omitted due to cytoplasmic positivity. An alternative antibody (CAB023879), showing a nuclear immunostaining pattern, has been added to the Protein Atlas.
  • The 2'-5'-oligoadenylate synthetase 2 antibody (HPA003320) has been omitted due to cytoplasmic positivity. An alternative antibody (CAB024984), showing a distinct nuclear immunostaining pattern, has been added to the Protein Atlas.
  • The Runt-related transcription factor 3 antibody (HPA004195) has been omitted due to cytoplasmic positivity. An alternative antibody (CAB025416), showing a nuclear immunostaining pattern, has been added to the Protein Atlas.
  • The Mitogen-activated protein kinase kinase 1-interacting protein 1 antibody (CAB004263) has been omitted due to nuclear positivity. An alternative antibody (HPA026858), showing a cytoplasmatic immunostaining pattern, has been added to the Protein Atlas.
  • The Moesin antibody (CAB004505) has been omitted due to positivity in nuclear membranes.
  • The Glutamate [NMDA] receptor subunit epsilon-1 Precursor antibody (HPA004692) has been omitted due to general positivity. An alternative antibody (CAB0022725), showing a more distinct immunostaining pattern in cns, has been added to the Protein Atlas.
  • The Guanine nucleotide-binding protein subunit beta-2-like 1 antibody (CAB004288) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Cardiac phospholamban antibody (CAB005597) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Zinc finger homeobox protein 4 antibody (HPA006176) has been omitted due to cytoplasmic positivity. An alternative antibody (HPA023837), showing a nuclear immunostaining pattern, has been added to the Protein Atlas.
  • The FK506-binding protein 8 antibody (HPA007054) has been omitted due to nuclear positivity. An alternative antibody (CAB025346), showing a cytoplasmic immunostaining pattern, has been added to the Protein Atlas.
  • The Hepatitis A virus cellular receptor 1 Precursor antibody (HPA007173) has been omitted due to lack of positivity in T-cells.
  • The Zinc finger and SCAN domain-containing protein 2 antibody (HPA007296) has been omitted due to cytoplasmic positivity. An alternative antibody (HPA024331), showing nuclear immunostaining pattern, has been added to the Protein Atlas.
  • The Tumor necrosis factor-inducible gene 6 protein Precursor antibody (HPA007896) has been omitted due to nuclear positivity.
  • The Endonuclease III-like protein 1 antibody (HPA008299) has been omitted due to cytoplasmic positivity. An alternative antibody (CAB025152), showing a nuclear immunostaining pattern, has been added to the Protein Atlas.
  • The Breast cancer metastasis-suppressor 1 antibody (CAB010824) has been omitted due to general positivity. An alternative antibody (HPA019637), showing a more distinct immunostaining pattern in placenta, has been added to the Protein Atlas.
  • The Neurofilament medium polypeptide antibody (HPA010900) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Gastrotropin antibody (HPA012601) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Neurofilament medium polypeptide antibody (HPA012976) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Dual specificity protein phosphatase 2 antibody (CAB016341) has been omitted due to cytoplasmic positivity.
  • The Zinc finger and SCAN domain-containing protein 21 antibody (HPA016948) has been omitted due to cytoplasmic positivity. An alternative antibody (HPA023591), showing a nuclear immunostaining pattern, has been added to the Protein Atlas.
  • The Group 3 secretory phospholipase A2 Precursor antibody (HPA018314) has been omitted due to rare positivity. An alternative antibody (HPA021016), showing a more ubiquitous immunostaining pattern, has been added to the Protein Atlas.
  • The Cyclin-A1 antibody (CAB019372) has been omitted due to diffuse cytoplasmic positivity.
  • The Forkhead box protein P3 antibody (HPA003191 and HPA008383) have been omitted due to cytoplasmic positivity. An alternative antibody (CAB026301), showing nuclear immunostaining pattern, has been added to the Protein Atlas.
  • The CD63 antigen antibody (CAB000062) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The Alkaline phosphatase, placental type Precursor antibody (CAB000067) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The Large Intestine Mucinous Antigen antibody (CAB000358) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The Proto-oncogene protein c-fos antibody (CAB000461) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The Kallikrein-6 Precursor antibody (CAB000463) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The SIMA antibody (CAB000468) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The Cystatin-B antibody (CAB000470) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The Hepatocyte nuclear factor 4-alpha antibody (CAB001387) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The Mitochondria antibody (CAB001516) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The Prohibitin antibody (CAB001517) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The Tubulin antibody (CAB001518) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The GRB2-associated-binding protein 1 antibody (CAB002605) has been removed from the protein atlas since it has been discontinued by the commercial distributor.
  • The CAB000026 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB000033 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB000044 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB000046 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB000049 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB000050 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB000056 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB000061 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB000138 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB000302 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA000519 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA000639 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA000754 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA001217 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA001245 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB001717 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB001810 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA001839 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB001997 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA002357 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA002539 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003009 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003034 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003052 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003065 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003181 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003182 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003212 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003214 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003285 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003532 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003540 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003550 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003644 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA003652 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA004008 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB004085 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA004110 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA004115 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB004271 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA004709 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA005736 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA006013 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA006766 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA007969 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB008641 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB008642 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB008643 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA009419 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB010402 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA011072 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB011453 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA012158 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB012703 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB012908 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA013409 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA013767 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA014796 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB014879 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA015013 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB015367 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB015377 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB015395 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA015509 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB016533 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB016726 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The CAB016789 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA017390 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA017595 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA018452 antibody has been removed from the protein atlas due to target gene not found in Ensembl.
  • The HPA018827 antibody has been removed from the protein atlas due to target gene not found in Ensembl.

Protein Atlas version 4.1 - 2008.12.03

  • Gene synonyms are now included in the database. The synonyms are searchable and displayed on the gene/protein-page. The gene synonyms are derived from Ensembl.
  • Western blot results with the validation score 3 (Single band larger than predicted size in kDa (+20%) but partly supported by predicted transmembrane region, signal peptide or by other available data.) have been moved from the validation category supportive (displayed as green) to the validation category uncertain (displayed as yellow).
  • The A-kinase anchor protein 4 precursor antibody (HPA005949) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Fructose-bisphosphate aldolase C antibody (HPA003282) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Solute carrier family 40 member 1 antibody (HPA011124) was removed from the Protein Atlas due to lack of positivity in entercytes.
  • The Synaptotagmin-like protein 4 antibodies (HPA001475 and HPA001589) were removed from the Protein Atlas due to lack of positivity in islet cells.
  • The Tyrosine-protein phosphatase non-receptor type 7 antibody (CAB0009530) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Bile salt export pump antibody (HPA0019035) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Collagen alpha-3(VI) chain precursor antibody (CAB002307) has been omitted due to immunostaining in most tissues including epithelial cells.
  • The NKG2-D type II integral membrane protein antibody (HPA001043) has been omitted due to diffuse cytoplasmic immunostaining.
  • The Catenin alpha-1 antibody (CAB000107) has been omitted due to nuclear staining.
  • The Cytokeratin AE1/AE3 antibody (CAB000025) has been omitted from the Protein Atlas due to representation of more than one gene.
  • The E3 ubiquitin-protein ligase UBR4 antibody (HPA013394) has been omitted due to nuclear staining.
  • The VIP peptides precursor antibody (CAB000573) was removed from the Protein Atlas due to lack of positivity in islet cells and periferial nerves.
  • The NGFI-A-binding protein 1 antibody (HPA002738) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Plexin-B2 precursor antibody (HPA003100) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • The Major prion protein precursor antibody (CAB005591) has been omitted from the Protein Atlas due to positivity in HEK293 cells.
  • The Pericentrin antibody (CAB005888) has been omitted from the Protein Atlas due to nuclear staining.
  • The Ephrin-B1 precursor antibody (CAB013501) has been omitted from the Protein Atlas due to nuclear staining.
  • The Argininosuccinate synthase antibody (CAB001953) has been omitted from the Protein Atlas due to weak and sparse cytoplasmic staining.
  • The DNA-binding protein inhibitor ID-3 antibody (CAB017119) has been omitted from the Protein Atlas due to cytoplasmic staining.
  • The Mitogen-activated protein kinase kinase kinase kinase 2 antibody (HPA012120) has been omitted from the Protein Atlas due to lack of positivity in B cells.
  • The Lysosomal-associated transmembrane protein 4B antibody (HPA014996) has been omitted from the Protein Atlas due to nuclear staining.
  • The Transmembrane protein 70 antibody (HPA014446) has been omitted due to diffuse cytoplasmic positivity.

Protein Atlas version 4.0 - 2008.08.18

  • [New] Fourth major release of the Human Protein Atlas with more than 6,000 antibodies and more than 5,700,000 images.
  • [New] All human protein-coding genes (Ensembl v50.36) have been included in the protein atlas.
  • [New] The proteins have now been classified according to a collection of protein classes.
  • [New] The antigen sequence for all HPA antibodies is now disclosed and visualized on the target protein sequence.
  • [Update] The search has been updated to make it possible to search for specific chromosomes, protein classes or protein expression patterns in cells.
  • [Change] The CDC25A antibody (CAB002674) has been omitted due to weak immunostaining. An alternative antibody (HPA005855), showing a more distinct immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The E3 SUMO-protein ligase PIAS1 antibody (HPA005743) has been omitted due to diffuse cytoplasmic and sparse nuclear immunostaining. An alternative antibody (CAB012304), showing a more distinct nuclear immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Protein CASP antibody (HPA003277) has been omitted due to non-reliable protein expression patterns (IHC).
  • [Change] The Phosphatidylinositol 3-kinase regulatory subunit alpha antibody (HPA001569) has been omitted due to non-reliable protein expression patterns (IHC).
  • [Change] The Neurogenic locus notch homolog protein 4 precursor antibody (CAB010183) has been omitted due to negative or weak cytoplasmic staining. An alternative antibody (CAB012331), showing a more distinct and ubiquitous immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Sequestosome-1 antibody (HPA003196) has been omitted due to weak and diffuse staining in some cells. An alternative antibody (CAB004587), showing a more distinct and ubiquitous immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Beta crystallin B1 antibody (HPA003101) has been omitted due to ubiquitous expression in most cells. The antibody should be eye specific.
  • [Change] The Transcription factor E2F1 antibody (CAB000120) has been omitted due to negative or weak staining in most cells. An alternative antibody (CAB000329), showing a more distinct nuclear immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The T-cell surface glycoprotein CD3 zeta chain precursor antibody (CAB002721) has been omitted due to ubiquitous staining in most cells. Alternative antibodies (CAB004651 and HPA008750), showing a more distinct immunostaining pattern in inflammatory cells, have been added to the Protein Atlas.
  • [Change] The Protein numb homolog (HPA002874) has been omitted due to lack of membranous staining in most cells. An alternative antibody (CAB011478), showing a more distinct membranous immunostaining pattern in most cells, has been added to the Protein Atlas.
  • [Change] The Major histocompatibility complex, class II, DM beta antibody (HPA007113) has been omitted due to ubiquitous staining in most cells. Alternative antibody (HPA012298), showing a more distinct immunostaining pattern in inflammatory cells, has been added to the Protein Atlas.
  • [Change] The Ephrin type-A receptor 7 precursor antibody (HPA000858) has been omitted due to negative or weak staining. An alternative antibody (CAB010496), showing a more distinct membranous immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Sodium/potassium-transporting ATPase subunit beta-1 antibody (CAB001989) has been omitted due to cytoplasmic staining. An alternative antibody (HPA012911), showing a more distinct membranous immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Nucleobindin-1 precursor antibody (CAB004677) has been omitted due to negative or weak staining. An alternative antibody (HPA008176), showing a more distinct ubiquitous cytoplasmic immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Cullin-4B antibody (HPA003046) has been omitted due to cytoplasmic positivity. Other alternative antibodies (CAB017786 and HPA011880), showing a more distinct nuclear immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Coagulation factor VIII precursor antibody (HPA001108) has been omitted due to absence of extra-cellular positivity. An alternative antibody (CAB018777), showing a more reliable immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The UDP-N-acetylhexosamine pyrophosphorylase antibody (HPA005897) has been omitted due to diffuse immunostaining pattern. An alternative antibody (HPA014659), showing a more reliable positivity, has been added to the Protein Atlas.
  • [Change] The Caspase-2 precursor antibody (CAB002046) has been omitted due to nuclear and cytoplasmic positivity. An alternative antibody (CAB012175), showing cytoplasmic immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Formimidoyltransferase-cyclodeaminase antibody (CAB001519) has been omitted due to diffuse and general cytoplasmic positivity. An alternative antibody (CAB016409), showing a more distinct cytoplasmic immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Glycogen synthase kinase-3 beta antibody (CAB005033) has been omitted due to diffuse cytoplasmic positivity. An alternative antibody (CAB016263), showing a more distinct cytoplasmic immunostaining pattern in eg neuronal tissues, has been added to the Protein Atlas.
  • [Change] The NF-kappa-B-repressing factor antibody (HPA001136) has been omitted due to the excistence of other redundant antibody (HPA001476).
  • [Change] The Zinc finger Y-chromosomal protein antibody (HPA000723) has been omitted due to diffuse cytoplasmic positivity. An alternative antibody (HPA001748), showing nuclear immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The HPA000629 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA0001862 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA005694 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA000634 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA000403 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA003060 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA007983 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA001383 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA006077 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA010873 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA002035 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA002127 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA000829 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA000764 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA000539 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA000452 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA001506 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA000289 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA001006 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA005552 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA002034 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA002192 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA000368 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA002925 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA001230 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA001625 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The HPA000951 and HPA000952 antibody has been omitted from the protein atlas due to overlapping antigen with antibody HPA001817 and HPA001832 (disagreement with the concept of independent antibodies for quality assurance).
  • [Change] The Adenomatous polyposis coli protein antibody (CAB002211) has been omitted due to sparse cytoplasmic positivity in goblet cells. An alternative antibody (HPA013349), showing a more general distinct cytoplasmic immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Alpha-type platelet-derived growth factor receptor precursor antibody (HPA004947) has been omitted due to unexpected positivity in some tissues. An alternative antibody (CAB018143), showing a more reliable immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Sulfotransferase family cytosolic 1B member 1 antibody (HPA002107) images have been omitted and replaced with images from a more recent staining with the same antibody.
  • [Change] The Interleukin-1 beta precursor antibody (HPA001410) has been omitted due to non-reliable nucleolar immunostaining pattern.
  • [Change] The prothrombin precursor antibody (HPA002970) has been omitted due to unexpected positivity in leukocytes. Two alternative antibodies (CAB016780 and CAB018650), showing a more distinct immunostaining pattern in serum, have been added to the Protein Atlas.
  • [Change] The C-X-C chemokine receptor type 3 antibody (HPA003189) has been omitted due diffuse nuclear staining. An alternative antibody (CAB017820), displaying a more reliable immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The Carcinoembryonic antigen-related cell adhesion molecule 5 precursor antibody (CAB000022) images have been omitted and replaced with images from a more recent staining with the same antibody.
  • [Change] The Myeloperoxidase precursor antibody (CAB000059) images have been omitted and replaced with images from a more recent staining with the same antibody.
  • [Change] The CAMP-responsive element modulator antibody (HPA001818) images have been omitted and replaced with images from a more recent staining with the same antibody.
  • [Change] The Collagen alpha-1(III) chain precursor antibody (HPA007583) images have been omitted and replaced with images from a more recent staining with the same antibody.

Protein Atlas version 3.1 - 2008.02.15

  • [New] A FAQ document (Frequently Asked Questions) has been added and is available as a link on the bottom of each page.
  • [New] Each image has now been complemented with more tissue information such as T-number and M-number as defined by SNOMED.
  • [Change] The term Staining intensity has been changed to Protein expression on several pages.
  • [Change] The ETS1-associated protein 1 (EAP1) antibody HPA008797 has been removed due to weak and unspecific staining. An alternative antibody HPA008736 is available on the Protein Atlas.
  • [Change] The Myeloid zinc finger 1 antibody (HPA001757) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • [Change] The E3 ubiquitin-protein ligase Praja1 antibody (HPA000595) stained images have been omitted and replaced with images from a more recent staining with the same antibody.
  • [Change] The WD repeat protein 13 antibody (HPA000239) has been omitted due to non-reliable protein expression patterns (IHC), showing mainly cytoplasmic positivity. An alternative antibody (HPA000913), displaying distinct nuclear staining, has been added to the Protein Atlas.
  • [Change] Medullar cells has been removed for adrenal gland.
  • [Change] Lymphoid tissue has been renamed to lymphoid cells in appendix.
  • [Change] Bone marrow poetic cells has been renamed to bone marrow poietic cells.
  • [Change] Surface epithelial cells has been renamed to respiratory epithelial cells in bronchus.
  • [Change] Non-neuronal cells has been renamed to glial cells in cerebral cortex.
  • [Change] Surface epithelial cells (squamous) has been renamed to squamous epithelial cells in cervix, uterine.
  • [Change] Endometrium has been renamed to corpus, uterine.
  • [Change] Cells in endometrial stroma/ECM has been renamed to cells in endometrial stroma in corpus, uterine.
  • [Change] Cells in myometrium/ECM has been removed for corpus, uterine.
  • [Change] Surface epithelial cells has been renamed to squamous epithelial cells in esophagus.
  • [Change] Non-neuronal cells has been renamed to glial cells in hippo campus.
  • [Change] Cells in tubuli has been renamed to cells in tubules in kidney.
  • [Change] Non-neuronal cells has been renamed to glial cells in lateral ventricle.
  • [Change] Follicle cells (cortex) has been renamed to reaction center cells in lymph node.
  • [Change] Non-follicle cells (paracortex) has been renamed to lymphoid cells outside reaction centra in lymph node.
  • [Change] Surface epithelial cells has been renamed to respiratory epithelial cells in nasopharynx.
  • [Change] Surface epithelial cells has been renamed to squamous epithelial cells in oral mucosa.
  • [Change] Exocrine pancreas has been renamed to exocrine glandular cells in pancreas.
  • [Change] Cells in ductus seminiferus has been renamed to cells in seminiferus ducts in testis.
  • [Change] Follicle cells (cortex) has been renamed to reaction center cells in tonsil.
  • [Change] Non-follicle cells (paracortex) has been renamed to lymphoid cells outside reaction centra in tonsil.
  • [Change] Surface epithelial cells has been renamed to squamous epithelial cells in tonsil.
  • [Change] Surface epithelial cells has been renamed to urothelial cells in urinary bladder.
  • [Change] Surface epithelial cells has been renamed to squamous epithelial cells in vagina.
  • [Change] Surface epithelial cells has been renamed to squamous epithelial cells in vulva/anal skin.
  • [Change] Colo-rectal cancer has been renamed to colorectal cancer.

Protein Atlas version 3.0 - 2007.10.09

  • [New] Third major release of the Human Protein Atlas with more than 3.000 antibodies and more than 2.800.000 images.
  • [New] Section for immunoflourescence staining of cell lines and confocal scanned images.
  • [New] Advanced search functionality enabling expression pattern search.
  • [New] Sort IHC tissues by alphabetic or histogenic order.
  • [New] Antibody specifility diagrams are now available for each HPA antibody based on array experiments. The diagrams can be found on the antibody info page.
  • [New] Western blot images are showed on selected antibodies on the antibody info page.
  • [Change] The SMC1 alpha protein antibody (HPA002855) has been omitted due to weak immunostaining. An alternative antibody (HPA005499), showing a more distinct immunostaining pattern, has been added to the Protein Atlas.
  • [Change] The TNF-R2 antibody (CAB002614) has been omitted due to a nuclear staining pattern. An alternative antibody (HPA004796), showing cytoplasmic and membranous positivity, has been added to the Protein Atlas.
  • [Change] The IL-1R-1 antibody (HPA001237) has been omitted due to a nuclear staining pattern. An alternative antibody (CAB007779) has been added to the Protein Atlas.
  • [Change] The LTF antibody (HPA001833) has been omitted due to deficient immunostaing with expected extra-cellular positivity. An alternative antibody (CAB008645) has been added to the Protein Atlas.
  • [Change] The FERM and PDZ domain-containing protein 3 antibody (HPA000830) has been omitted due to unspecific staining pattern.
  • [Change] The MMP-3 antibody (CAB002747) has been omitted due to low quality immunostaining pattern with only sparse positivity in mucous producing cells.
  • [Change] The AMOT antibody (CAB003708) has been omitted due to lack of expected positivity in endothelial cells.

Protein Atlas version 2.0 - 2006.10.30

  • [New] Second major release of the Human Protein Atlas with more than 1.500 antibodies and 1.000.000 images.
  • [New] Cell profiles have been added to complement the tissue profiles. The new profiles consist of 47 cell lines and 12 primary cells that have been stained with HPA antibodies and evaluated using automated image analysis. The results are presented at the bottom of the expression profile-page for almost every antibody.
  • [Change] Due to late finding of an incorrect molecular weight of the antigens for HPA001340 and HPA001660, these antibodies were removed.
  • [Change] Due to weak and unspecific staining using the CDC2 antibody, CAB002435, a new immunostaining and subsequent annotation has been performed using the alternative antibody, CAB003799.

Protein Atlas version 1.2 - 2006.03.13

  • [Change] The underlying algorithms for color code representation of negative, weak, moderate and strong staining has been modified. In the updated version, an immunostaining of less than 25% of the recorded cell type has been given less weight compared to the previous version. The result provides a more accurate display of the represented immunostained cell population.
  • [Change] In the previous version, tissues with one or several cell types missing were shown as a negative (white) color code. In the present version, this has been changed so that all cell types now displayed as negative (white) correctly represent existing cell types that lack immunohistochemical staining. The color code black (Not representative) has now been extended to include both not representative images as well as images where cell types are missing. The overall result will be an increase of displayed cell types as "Not representative" (black).
  • [Change] The explanation for a black color code on the summary page has been changed from "No images" to "Not representative".
  • [Change] A new design of the table displaying the splice variants for each gene.
  • [Update] Due to a weak and unspecific staining of the Integrin antibody, CAB003434, a new immunostaining has been performed using the same antibody. Images and annotation has been updated and the old version, CAB000127, has been removed.

Protein Atlas version 1.1 - 2005.11.11

  • [Change] Changes have been made in the presentation of annotated localization patterns. Previous version included 4 different parameters for describing subcellular localization of protein expression: i) nuclear, ii) cytoplasmic, iii) membrane and iv) extra cellular. In the present version cytoplasmic and membraneous localization have been merged so that the output parameters now are i) nuclear, ii) cytoplasmic and/or membraneous. Due to the level of resolution using enzyme-based immunohistochemistry it is not possible to distinguish between cytoplasmic and membraneous localization in cells with a small cytoplasm. Cytoplasmic and membraneous localization has consequently been changed to one shared output parameter. Extra cellular localization has been omitted as a localization parameter given for a cell type. Corresponding text concerning annotation in “about protein atlas” has been modified accordingly.
  • [Change] A new summary page has been created. Previous version included two different summary pages, one for normal tissues and one for cancer tissues as well as a summary page containing all antibody information. In the present version the summary page contains a short gene description and a summary of both normal and cancer tissues.
  • [New] A new tab on the start page has been inserted. The new tab represents a “submission of antibodies” and contains a call for antibodies, information and an application form. Previous version included a tab “collaborations” which has been omitted.
  • [Update] Reliabilty scores have been curated for a subset of antibodies in the protein atlas since new data has allowed for detailed validation. A validation comment text has been added in these cases.
  • [New] The possibility to reference or link into a particular antibody in the Protein Atlas has now been simplified. The Protein Atlas now supports links in the following two new formats: HUGO ID and Ensembl gene ID. Examples of the new URLs:
    http://www.proteinatlas.org/tissue_profile.php?hugo_id=bmx
    or
    http://www.proteinatlas.org/tissue_profile.php?ensembl_gene_id=ENSG00000102010
  • [New] Version history (this text) has been added as text under the tab “about protein atlas”.

Protein Atlas version 1.0 - 2005.08.29

  • First release of the Protein Atlas. Atlas content: 718 antibodies and 413,568 images


home | about protein atlas - release history

  Send questions, comments or suggestions to: contact@hpr.se. |  FAQ / Help
KTH UU