The human protein atlas blog

Potential new tool for measuring beta cell mass

Beta cells Diabetes Pancreas Proteome Tissue Atlas

Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in islet cells.

In a recent study, scientists including members of The Human Protein Atlas project have identified the beta cell specific protein GPR44 as a potentially novel tool for measuring beta cell mass in vivo, using radiolabeled PET ligands targeting GPR44.

The pancreatic beta cell is responsible for producing insulin and beta cell loss is one of the causes underlying diabetes. Blood biomarkers to measure beta cell function exist, but there is a lack of good tools for measuring the beta cell mass inside the body.

In this study, the ligand targeting GPR44 was compared to a ligand targeting the established beta cell marker VMAT2, and the performance was evaluated...Read more

Image of the week - Centrosomes from CalebAyrania

Citizen Science Project Discovery Subcell Atlas

Staining of mitotic centrosomes (green) with tubules (red) and DNA (blue) in CACO-2 cells.

Introducing the HPA image of the week! Each week we will pick an image we find particularly interesting and briefly discuss it. This series will particularly focus on images brought to us by citizen scientists working on Project Discovery, though may include images from other projects in the atlas as well.

This week's image is brought to us by citizen scientist CalebAyrania who found this staining playing Project Discovery and correctly identified the antibody as labeling centrosomes in mitotic cells (cells undergoing division). This staining was observed in CACO-2 colorectal epithelial adenocarcinoma cells...Read more

The uterine endometrium-specific proteome defined

Endometrium Proteome Tissue Atlas

In a recent study by co-workers of The Human Protein Atlas project over 100 genes with elevated expression pattern in the normal endometrium was found. A majority of these genes are well-known and have been extensively characterized. However, the list of endometrium-specific genes also includes uncharacterized genes, providing starting points for further studies of their role in normal homeostasis and diseases affecting the endometrium.

The uterus contains the endometrial mucosa which is the site for embryo implantation...Read more

Project Discovery - Day 1 results

CCP Citizen Science EVE Online Human Protein Atlas MMOS Project Discovery Proteome

Fig. 1. Confusion matrix of gamer predictions versus HPA predictions. Here columns represent votes of gamers. Confusions occurring with a frequency below 1% are set to black for clarity.

Thanks Science Fans!

The response to Project Discovery has been amazing and overwhelming. You have taken to the game in a way none of us expected. Keep it up!

First, in an effort to stream line our interactions with you we have created a number of official social media outlets:

EVE forums: We have a number of official accounts we will respond to questions with.Twitter: HPA_Discovery - dedicated to posting updates, announcements and all things Project Discovery. Twitter is severely character limited so it's difficult to answer questions there.Reddits: /r/EVE and /r/projectdiscovery - We will be here for support as well...Read more

Project Discovery - a contribution to Science


The proteins are the building blocks of life

The human body is built of organs and tissues, each organ and tissue constitute of groups of cells, and each cell is built from a set of proteins - the building blocks of life.

In total, the human body consists of 100 billion cells, in every cell the genetic code translate to a set of proteins that will give the cell its specific properties.

Our mission is to map all proteins in the human body to better understand health and disease.

In order to identify the subcellular localization of proteins in cells, millions of images have been taken within the Human Protein Atlas project...Read more