Let‘s have a look at the protein TPX2, a microtubule nucleation factor that translocates from the nucleus - where it resides during interphase - to the mitotic spindle during mitosis.

The mitotic spindle forms when chromosomes are ready to segregate during cell division and not surprisingly this protein is also found in this specific compartment of the cell! TPX2 is required for the correct formation of the kinetochores that is crucial for the attachment of microtubules, enabling the sister chromatids to be pulled apart.

TPX2 is a clinically relevant protein that has kept cancer researchers busy during the recent years due to aberrant expression patterns found among various tumor types, especially in colon cancer where it has been shown to be overexpressed in metastatic lesions and therefore considered a prognostic marker for the gain of metastatic capabilities. Due to its role in formation of tumors and metastases, TPX2 is also a potential therapeutic target for the disease.

Frida Danielsson