The human protein atlas blog


Image of the week - CDC42 and actin filaments

2016-05-06
Actin Cell cycle Image of the week Immunofluorescence Subcell Atlas

Fig 1. Staining of CDC42EP4 (green) with DAPI (blue) and microtubules (red) in U2 OS cells.

This week HPA image of the week, I've decided to highlight two of my favorite things, the cell cycle and actin filaments!

The protein labeled in Fig 1. is an image of Cell division cycle 42 effector protein (Rho GTPase binding) 4 (CDC42EP4). In addition to being quite a mouthful, this protein resides in the cytoplasm and is associated with the actin filaments. In this image, CDC42EP4 is seen in U-2 OS human osteosarcoma cells.

As the name suggests, the CDC42EP4 is a protein associated with CDC42, which helps regulate the transition from G1 to S (in which DNA is replicated), and is essential for proper cell cycle progression (Yasuda S et al. 2006)...Read more