The human protein atlas blog


Biomarker for prostate cancer

2016-11-01
Autoantibody Biomarkers Prostate Proteomics

Fig1. Workflow

In a recent study in Journal of Proteome Research by Human Protein Atlas-researchers a new reactive epitope of a prostate specific protein, particularly reactive in the late stages of prostate cancer is identified.

According to WHO, prostate cancer is the second most incident cancer in men and the fifth leading cause of death in men worldwide, and there is a demand for novel targets and approaches to diagnose and treat this cancer type. Five-year survival is reached by almost 100% of patients if the disease is still at a local and regional stage; however, the survival rate drops down to 30% in the case of aggressive form with distant metastasis and relapse after treatment...Read more


Novel assay concept developed

2016-09-13
Antibody Microarray Autoantibody Multiple Sclerosis Proteomics

Burcu Ayoglu

In an article in a special edition of Proteomics, on protein arrays researchers from the Human Protein Atlas describe the development of a novel assay concept, which combines the flexibility and multiplexing capacity of single-binder assays and the specificity and sensitivity aspects of dual-binder assays. They developed a multiplexed dual-binder assay procedure, which is based on a sequential protein capture.

– This assay is a great addition to the antibody-array toolbox of the Biobank Profiling Group, both to support related assay development activities and for biomarker discovery applications, says Burcu Ayoglu, first author of the study...Read more


Autoantibody targets in narcolepsy

2016-05-31
Autoantibody Autoimmunity Proteomics Vaccine

Anna Häggmark

A new study by researchers within the Human Protein Atlas project was just published in Autoimmunity .

The researchers analyzed the presence of autoantibodies in patients with vaccine-associated narcolepsy. In an initial screening, IgG reactivity to approximately 10000 protein fragments was investigated, revealing a large heterogeneity in which autoantibodies that are present in different individuals.

Anna Häggmark is the first author of the paper...Read more


Investigating autoantibody reactivity in lungs

2016-01-12
Autoantibody Autoimmunity Microarray Sarcoidosis

A study of autoimmune targets in sarcoidosis revealed higher reactivity in patients compared to controls for four proteins in both bronchoalveolar lavage (BAL) and serum.

Proteomic Profiling Reveals Autoimmune Targets in Sarcoidosis

Sarcoidosis is an inflammatory lung disease with unknown cause. Previous research has shown that sarcoidosis patients have generally higher levels of antibodies compared to healthy controls but so far the role and protein targets of these antibodies are not well understood.

In this study we used protein microarrays to investigate autoantibody targets in bronchoalveolar lavage (BAL) fluid in the search for autoantigens associated to disease...Read more