THE HUMAN PROTEIN ATLAS BLOG

The cancer proteome

2016-08-09   |   0 Comments
Cancer Immunocytochemistry Proteome

Tumor protein p53 in colorectal cancer

Cancer can be defined as a common heterogeneous and potentially deadly disease that affects approximately 1/3 of the human population. The common denominator for cancer is the development of an uncontrolled growth of cells that eventually leads to multiple organ failure and death.

The cancer proteome is based on genes that are implicated in cancer. Expression of these genes in normal cells contributes to normal growth, survival and function, whereas dysregulated expression, including overexpression, loss of expression or expression of a defect protein in cancer cells contributes to ungoverned tumor growth...Read more


Profiling cancer testis antigens

2016-07-12   |   0 Comments
Cancer Testis

Dijana Djureinovic, the first author of the study

In a recent publication in JCI Insight researchers from the Human Protein Atlas have described the expression of the currently known cancer-testis antigens (CTAs) in non-small cell lung cancer, and have added 50 new CTAs to this list.

Lung cancer is the most common cause of cancer related death in Sweden and worldwide. Most patient present with advanced disease and have a short life expectancy despite modern therapy.

Dijana Djureinovic is a PhD student in the group of Cecilia Lindskog at Science for Life Laboratory. She started her PhD studies two years ago, but worked in the project before that, on antibody validation...Read more


Biomarker for prognosis in endometrial carcinoma

2016-03-01   |   0 Comments
ASRGL1 Cancer Endometrial Carcinoma Microarray Tissue Atlas

Reduced expression of ASRGL1 was significantly associated with poor prognosis and reduced disease-specific survival.

Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma

The ASRGL1 protein is a novel, powerful, and independent biomarker for prognosis in endometrial carcinoma.

In a recent study by scientists from the Human Protein Atlas project and collaborators at the University of Bergen and University of Turku, the l-asparaginase (ASRGL1) protein was identified as an endometrial carcinoma biomarker candidate by searches in the HPA-database.

ASRGL1 expression was immunohistochemically evaluated on two large independent endometrial carcinoma cohorts using an extensively validated antibody...Read more


The human prostate proteome

2016-02-09   |   0 Comments
Cancer Prostate Proteome Tissue Atlas

The definition of the prostate specific proteome provides a starting point for further studies exploring the molecular repertoire of the prostate.

Novel biomarkers for prostate cancer found while defining the prostate specific transcriptome and proteomeTo better understand the function of the prostate and diseases associated with it, it is important to explore the molecular constituents that make up the prostate gland.

In a recent study by scientists from the Human Protein Atlas project and colleagues both gene and protein expression profiles were investigated in prostate tissue and compared to 26 other human tissues. The aim was to identify potential prostate specific biomarkers for potential clinical use...Read more


From primary to malignant - what changes?

2016-01-19   |   0 Comments
Cancer Malignant transformation Model system Proteomics Transcriptomics

Three examples of differentially expressed proteins during malignant transformation in a four step fibroblast cell line model.

Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model

From primary to malignant - what changes? Bridging transcriptomics and proteomics to reveal the molecular changes during malignant transformation in a four-step cancer cell line model

In order to find out more about the changes that occur when a primary cell is transformed into an aggressive cancer cell, integration of biological information has proven to be successful. By bridging transcriptomics and antibody based proteomics data we showed how the major changes during malignant transformation could be scrutinized...Read more


A prognosis based classification of uterin cancer

2015-12-01   |   0 Comments
Cancer Microarray Tissue Atlas Undifferentiated uterine sarcoma

The ovaries, fallopian tubes, and uterus

A prognosis based classification of undifferentiated uterine sarcomas: Identification of mitotic index, hormone receptors and YWHAE-FAM22 translocation status as predictors of survival

Undifferentiated uterine sarcomas (UUS) are rare tumors with a heterologous biology and a poor prognosis.

In a recent study by scientists from the Human Protein Atlas project and colleagues, the relevance of clinicopathology, mitotic index, translocation status (YWHAE-FAM22), and a number of biomarker candidates were examined for correlation with the prognosis of these tumors. The protein biomarkers P53, P16, Ki-67, Cyclin-D1, ER, PR, and ANLN were evaluated by immunohistochemistry...Read more


Prognostic impact of COX-2 in lung cancer

2015-11-17   |   0 Comments
Cancer COX-2 Lung cancer Microarray Tissue Atlas

COX-2 expression in stroma

Prognostic impact of COX-2 in NSCLC: a comprehensive compartment-specific evaluation of tumor and stromal cell expression

In a study performed by scientists at Uppsala University, in collaboration with Gothenburg University and the Human Protein Atlas project, the expression of cyclooxygenase-2 (COX-2) was evaluated in patients with non-small cell lung cancer (NSCLC)...Read more


Elevated expression of CD93 in brain tumor

2015-11-03   |   0 Comments
Brain cancer Cancer CD93 Glioblastoma Tissue Atlas

CD93 expression in pathological blood vessels in a case of high-grade malignant glioma

Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival

CD93 encodes for a cell-surface glycoprotein and is expressed in myeloid cells and endothelial cells. CD93 has recently been identified as an important gene in primary tumor angiogenesis and the corresponding protein has been shown to have proangiogenic properties. In the present study the role of CD93 in malignant glioma was analyzed. The effect on glioblastoma vessels and tumor growth was studied...Read more