THE HUMAN PROTEIN ATLAS BLOG

Structural epitope mapping for precision medicine

2017-02-21
Epitope mapping

Anna-Luisa Volk, PhD student and first author of the study

The term precision medicine describes the idea of providing effective treatment based on a patient´s molecular make up.

Eculizumab is used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical haemolytic uremic syndrome (aHUS). However, eculizumab is a very expensive drug, and the treatment is not efficient for all patients...Read more


Stratification of patients using epitope mapping

2016-08-16
Complement system Deep mutational scanning Epitope mapping Precision medicine

To allow for precision medicine the genome of patients is sequenced to identify possible variations of the target gene.

In a paper published in Nature Scientific Reports last week, researchers from the Human Protein Atlas describe a method for stratification of responders towards the drug eculizumab that allows for precision medicine and should be applicable to several other diseases and therapeutics.

The term precision medicine describes the idea of providing effective treatment based on a patientīs molecular make up. Recent advances in molecular diagnostic tools and handling of large data sets allow for the stratification of patients based on e.g. genetic or protein information and make it possible to provide tailored treatment for these sub-groups...Read more