The human protein atlas blog

On epitope mapping and therapeutic antibodies

Antibody Antibody Microarray Epitope mapping

Johan Rockberg

Today we meet yet another researcher within the Human Protein Atlas project, Johan Rockberg, Associate Professor in antibody technology and directed evolution at KTH - Royal Institute of Technology in Stockholm, Sweden. He is the group leader for the epitope mapping and therapeutic antibodies group within the Human Protein Atlas.

– I have a M. Sc in chemical engineering from KTH and University of Sydney and joined the Human Protein Atlas Project in 2003, right in the beginning. Since I took courses in computational and information science in parallel with chemical engineering it was natural to pursue a career in bioinformatics...Read more

Structural epitope mapping for precision medicine

Epitope mapping

Anna-Luisa Volk, PhD student and first author of the study

The term precision medicine describes the idea of providing effective treatment based on a patient´s molecular make up.

Eculizumab is used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical haemolytic uremic syndrome (aHUS). However, eculizumab is a very expensive drug, and the treatment is not efficient for all patients...Read more

Stratification of patients using epitope mapping

Complement system Deep mutational scanning Epitope mapping Precision medicine

To allow for precision medicine the genome of patients is sequenced to identify possible variations of the target gene.

In a paper published in Nature Scientific Reports last week, researchers from the Human Protein Atlas describe a method for stratification of responders towards the drug eculizumab that allows for precision medicine and should be applicable to several other diseases and therapeutics.

The term precision medicine describes the idea of providing effective treatment based on a patientīs molecular make up. Recent advances in molecular diagnostic tools and handling of large data sets allow for the stratification of patients based on e.g. genetic or protein information and make it possible to provide tailored treatment for these sub-groups...Read more