THE HUMAN PROTEIN ATLAS BLOG

Computational scientist with a focus on the liver

2016-08-30   |   0 Comments
Liver Systems biology

Adil Mardinoglu

Adil Mardinoglu is a SciLifeLab fellow and the newest addition to the Protein Atlas team of principal investigators. He is the leader of the systems biology group, a group that create biological networks to identify drug targets and discover biomarkers for the development of efficient treatment strategies.

But Adil┤s background is not in medicine, he is an electronic engineer with a PhD in computational biology.

– I did my PhD in Ireland where I worked with magnetic drug targeting, he says.

After a one year post doc doing research on neuronal networks, Adil Mardinoglu moved to Chalmers in Gothenburg to join Jens Nielsens group in systems biology...Read more


Integrated networks for obese subjects

2016-08-02   |   0 Comments
Liver Metabolism Metabolomics

Graphical representation of the investigation

In a paper in a recent issue of Cell Metabolism, Human Protein Atlas-researchers investigate the biological processes that are altered in obese subjects.

Obesity is associated with an increased risk for a wide range of morbidities, including insulin resistance, type 2 diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. Although the prevalence of obesity continues to dramatically increase worldwide, a clear understanding of the underlying molecular mechanisms involved in the progression of associated disorders is still lacking...Read more


A systems approach to the liver

2016-07-26   |   0 Comments
Genomics Liver Metabolomics Phenomics Proteomics Transcriptomics

Multiscale -omics technologies and integrated network approaches unveiled the link between genetic variance and phenotypic differences in liver.

In a recent number of Nature Reviews, Human Protein Atlas researchers Mathias UhlÚn and Adil Mardinoglu discuss a study by E.G. Williams and co workers in Science where five complementary -omics datasets across various environmental states (including genomics, transcriptomics, proteomics, metabolomics and phenomics) using the liver as a platform for multiomics analysis are integrated...Read more


Proteins in drug-induced liver injuries

2016-06-07   |   0 Comments
Affinity proteomicsBiomarkers Drug development Liver

Maria Mikus - first author of the study

Last week, researchers from the Human Protein Atlas, together with others, published a study on drug-induced liver injury in the journal Liver International.

Drug-induced liver injury is the single leading cause for termination of drug development and safety-related withdrawal of approved drugs from the market. In clinical practice, it accounts for more than 50% of liver failure cases and represents a major safety issue for patients. In some patients, drug-induced liver injury can cause severe injury leading to acute liver failure that can be life threatening and require liver transplantation...Read more


Aquaporin 9 expression in human tissue

2016-05-10   |   0 Comments
Hepatocellular Carcinoma Human Protein Atlas Liver Tissue Atlas

Protein expression of aquaporin 9 in normal tissues

In a very recent paper in Journal of Histochemistry and Cytochemistry , with researchers from the Human Protein Atlas, it is shown that the expression of aquaporin 9 is limited in normal tissues, and high membranous expression is observed only in hepatocytes.

Aquaporin 9 is known to facilitate hepatocyte glycerol uptake. Murine aquaporin 9 protein expression has been verified in liver, skin, epididymis, epidermis and neuronal cells using knockout mice.

One goal of the current study was to systematically explore the distribution of aquaporin 9 expression in humans...Read more