The human protein atlas blog

Cell Image of the Month - It is Taco Friday!

Cell Atlas Image of the week Mitochondria

Antibody HPA021643 in U-2 OS recognizing TACO1 in mitochondria.

Today we highlight another part of Swedish or Scandinavian (food) culture - "Taco Fredag" or "Taco Friday". Doesn't sound Swedish to you? But staying in on a Friday night and having tacos with your family and/or friends is a thing here, and a big thing as it happens, with supermarkets having entire sections dedicated to this tradition.

So what other image to look at in this week's edition of the Human Protein Atlas blog than the one representing TACO1. TACO1 acts as a translational activator for the mitochondrial encoded cytochrome c oxidase 1, which is a component of complex IV of the mitochondrial respiratory complex...Read more

Mad about Mitochondria

Cell Atlas Mitochondria Subcell Atlas

Mikaela Wiking

This week, it is Mitochondrial Disease Awareness Week. Therefore we would like to take the opportunity to talk about the mitochondrial proteome, the work we do within this field, and you will even get to meet one of our researchers, involved in this work.

The mitochondria are distributed throughout the cytoplasm of the cell, each organelle enclosed by a double membrane, the inner one forming the characteristic folds known as cristae. Mitochondria are essential for producing the cell´s need of ATP through cellular respiration, but have also been shown to participate in many other cellular functions, including apoptosis, calcium storage and cellular signaling...Read more

Image of the week - Mitochondria by Illuminator

Image of the week Mitochondria Subcell Atlas

Figure 1. Staining of TOMM5 (green) with DNA (blue) in HeLa cells.

Welcome back to Image of The Week! We will be periodically highlighting an organelle in the coming image of the week posts, written by members of the Subcellular Human Protein Atlas project. This week we kick things off with a post by HPA_Illuminator, and what better way to start than with the mitochondria, the (true) powerhouse of the cell!!!

Mitochondria are found in almost all human cells, in varying numbers. They are known as the powerhouse of the cell as they are responsible for producing the majority of the energy in your body (in the form of ATP, adenosine triphosphate)...Read more

Image of the week - FDXR by solartech0

Citizen Science Image of the week Mitochondria Project Discovery Subcell Atlas

Figure 1. Staining of FDXR (green) with DNA (blue) and microtubules (red) in A549 cells.

Welcome to HPA image of the week! This week's image was brought to us by citizen scientists in Project Discovery, and specifically by solartech0 who found this image while playing Project Discovery in EVE online.

The protein stained in Fig 1. is an image of ferredoxin reductase (FDXR) found in the mitochondria of the cell. This sample shows a staining of FDXR in A549 adenocarcinomic alveolar basal epithelial cells.

FDXR is a protein involved in cellular metabolism. This process is what provides energy for our cells and is carried out in the mitochondria of the cell...Read more