THE HUMAN PROTEIN ATLAS BLOG

From primary to malignant - what changes?

2016-01-19
Cancer Malignant transformation Model system Proteomics Transcriptomics

Three examples of differentially expressed proteins during malignant transformation in a four step fibroblast cell line model.

Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model

From primary to malignant - what changes? Bridging transcriptomics and proteomics to reveal the molecular changes during malignant transformation in a four-step cancer cell line model

In order to find out more about the changes that occur when a primary cell is transformed into an aggressive cancer cell, integration of biological information has proven to be successful. By bridging transcriptomics and antibody based proteomics data we showed how the major changes during malignant transformation could be scrutinized...Read more