The human protein atlas blog

Image of the week - Nuclear speckles, Selphentine

Citizen Science Image of the week Nuclear speckles Project Discovery Subcell Atlas

Fig 1. Staining of DDX39B (green) with tubules (red) and DNA (blue) in MCF-7 cells.

Welcome to another HPA image of the week! This week's image was brought to us by citizen scientists in Project Discovery, and specifically by Selphentine who pointed out several nice examples of proteins localized to "nuclear speckles". In Project Discovery, citizen scientists are refining our annotations for proteins within the nucleus by labeling these nuclear speckles, previously not annotated in the atlas.

The protein stained in Fig 1. is an image of DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) seen in the nuclear speckles. This sample shows MCF-7 cells, a human adenocarcinoma cell line from breast cancer...Read more