THE HUMAN PROTEIN ATLAS BLOG

Potential new tool for measuring beta cell mass

2016-03-29
Beta cells Diabetes Pancreas Proteome Tissue Atlas

Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in islet cells.

In a recent study, scientists including members of The Human Protein Atlas project have identified the beta cell specific protein GPR44 as a potentially novel tool for measuring beta cell mass in vivo, using radiolabeled PET ligands targeting GPR44.

The pancreatic beta cell is responsible for producing insulin and beta cell loss is one of the causes underlying diabetes. Blood biomarkers to measure beta cell function exist, but there is a lack of good tools for measuring the beta cell mass inside the body.

In this study, the ligand targeting GPR44 was compared to a ligand targeting the established beta cell marker VMAT2, and the performance was evaluated...Read more