The human protein atlas blog


Transcriptomics data from FANTOM program

2017-02-13
RNA RNA-seq Transcriptome Transcriptomics

Overview of the tissues and organs analysed by HPA, FANTOM and GTEx

In the latest version of the Human Protein Atlas, released in December 2016, the tissue atlas data is complemented with RNA-data from The Functional Annotation of Mammalian Genomes 5 (FANTOM5) project in RIKEN, Japan. The FANTOM data greatly overlaps with the Human Protein Atlas data, strengthening the results from both the projects.

The human genome consists of DNA which is transcribed into functional protein-coding transcripts (mRNA) and in turn is translated into proteins, the functional building-blocks of the cell. The entirety of mRNA molecules in a cell or tissue is called the "transcriptome"...Read more


A systems approach to the liver

2016-07-26
Genomics Liver Metabolomics Phenomics Proteomics Transcriptomics

Multiscale -omics technologies and integrated network approaches unveiled the link between genetic variance and phenotypic differences in liver.

In a recent number of Nature Reviews, Human Protein Atlas researchers Mathias UhlÚn and Adil Mardinoglu discuss a study by E.G. Williams and co workers in Science where five complementary -omics datasets across various environmental states (including genomics, transcriptomics, proteomics, metabolomics and phenomics) using the liver as a platform for multiomics analysis are integrated...Read more


The urinary bladder proteome defined

2016-04-05
Proteome Tissue Atlas Transcriptomics Urinary bladder

Immunohistochemistry-based protein profiling of elevated genes in urinary bladder that are expressed in umbrella cells.

To understand the molecular functions of the urinary bladder, researchers including scientists from The Human Protein Atlas project have recently defined the expression of elevated genes in the bladder.

The main function of the urinary bladder is to store the urine made by the kidneys, allowing urination voluntarily. The urothelium also plays an important role in preventing rupture of urine storage and leakage of toxic urinary substances into the blood...Read more


From primary to malignant - what changes?

2016-01-19
Cancer Malignant transformation Model system Proteomics Transcriptomics

Three examples of differentially expressed proteins during malignant transformation in a four step fibroblast cell line model.

Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model

From primary to malignant - what changes? Bridging transcriptomics and proteomics to reveal the molecular changes during malignant transformation in a four-step cancer cell line model

In order to find out more about the changes that occur when a primary cell is transformed into an aggressive cancer cell, integration of biological information has proven to be successful. By bridging transcriptomics and antibody based proteomics data we showed how the major changes during malignant transformation could be scrutinized...Read more