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Cell Dictionary
 
Myeloid
Cell line Description of cell line Original reference Origin Sex Age Source
HEL Erythroleukemia cell line (AML M6 in relapse after treatment for Hodgkin's disease) Martin et al., Science 216: 1233 (1982) peripheral blood M 30 DSMZ
HL-60 Acute promyelocytic leukemia (APL) cell line Collins et al., Nature 270: 347-349 (1977) peripheral blood F 35 DSMZ
HMC-1 Mastcell leukemia cell line Butterfield et al., Leukemia Res. 12: 345-355 (1988) peripheral blood M 52 KN1
K-562 Chronic myeloid leukemia (CML) cell line Lozzio et al., J Natl Cancer Inst 50: 535 (1973) pleural effusion F 53 DSMZ
NB-4 Acute promyelocytic leukemia (APL) cell line Lanotte et al., Blood 77: 1080 (1991) bone marrow F 23 DSMZ
THP-1 Acute monocytic leukemia (AML) cell line Tsuchiya et al., Int J Cancer 26: 171 (1980) peripheral blood M 1 DSMZ
U-937 Myelomonocytic histiocytic lymphoma cell line Sundström C, Nilsson K., Int J Cancer 17:565-577 (1976) pleural effusion M 37 KN1
 
Lymphoid
Cell line Description of cell line Original reference Origin Sex Age Source
Daudi Human Burkitt lymphoma cell line Klein et al., Cancer Res 28: 1300 (1968) orbital biopsy M 16 DSMZ
HDLM-2 Hodgkin lymphoma cell line Drexler et al., Leuk Res 10: 487 (1986) pleural effusion M 74 DSMZ
Karpas-707 Multiple myeloma cell line Karpas et al., Lancet Apr 24;1(8278): 931-3 (1982) bone marrow and peripheral blood M 53 KN1
KM3 B-cell leukemia cell line (ALL, second relapse) Schneider et al., Int J Cancer 19: 621-626 (1977) peripheral blood M 12 DSMZ*
LP-1 Multiple myeloma cell line Pegoraro et al., Blood 73: 1020 (1989) peripheral blood F 56 DSMZ
MOLT-4 Acute lymphoblastic leukemia (T-ALL) cell line Minowada et al., J Natl Cancer Inst 49: 891 (1972) peripheral blood M 19 DSMZ
RPMI-8226 Multiple myeloma cell line Matsuoka et al., Proc Soc Exp Biol Med 125: 1246 (1967) peripheral blood M 61 DSMZ
U-266/70 Multiple myeloma cell line (1970, IL-6-dependent) Nilsson et al Clin Exp Immunol 7:477-489 (1970) peripheral blood M 53 KN1
U-266/84 Multiple myeloma cell line (1984, in vitro differentiated) Hellman et al., Eur J Immunol 18:905-910 (1988) peripheral blood M 53 KN1
U-698 B-cell lymphoma cell line (lymphoblastic lymphosarcoma) Nilsson et al., Int J Cancer 13: 808-823 (1974) tonsil M 7 DSMZ
 
Brain
Cell line Description of cell line Original reference Origin Sex Age Source
D341 Med Medulloblastoma cell line Friedman et al. Am. J. Pathol. 130: 472 (1988) brain M 3 LGC/ATCC
SH-SY5Y Metastatic neuroblastoma, clonal subline of neuroepithelioma cell line SK-N-SH Biedler et al., Cancer Res 33: 2643 (1973) bone marrow F 4 DSMZ
U-138MG Glioblastoma cell line Ponten et al., Acta Pathol Microbiol Scand 74: 465 (1968) brain M 47 DSMZ
U-251MG Glioblastoma cell line Westermark B., Int J Cancer12: 438 (1973) brain M 0 BW2
U-87MG Glioblastoma, astrocytoma cell line ** brain F 44 LGC/ATCC
 
Lung
Cell line Description of cell line Original reference Origin Sex Age Source
A-549 Lung carcinoma cell line Giard et al., J Natl Cancer Inst 51: 1417 (1973) lung M 58 DSMZ
SCLC-21H Small cell lung carcinoma cell line Bepler et al., J Cancer Res Clin Oncol 113: 31 (1987) pleural effusion M 46 DSMZ
 
Abdominal
Cell line Description of cell line Original reference Origin Sex Age Source
CACO-2 Colon adenocarcinoma cell line Fogh J., et al. J. Natl. Cancer Inst. 58: 209 (1977) colon M 72 DSMZ
CAPAN-2 Pancreas adenocarcinoma cell line Kyriazis et al., Cancer Res 46: 5810 (1986) pancreas M 56 DSMZ
Hep-G2 Hepatocellular carcinoma cell line Aden et al., Nature 282: 615 (1979) liver M 15 DSMZ
 
Breast, female reproductive system
Cell line Description of cell line Original reference Origin Sex Age Source
AN3-CA Metastatic endometrial adenocarcinoma cell line Dawe et al., J Natl Cancer Inst 33: 441 (1964) lymph node F 55 DSMZ
EFO-21 Metastatic ovarian serous cystadenocarcinoma cell line Simon et al., J Natl Cancer Inst 70: 839 (1983) ascites F 56 DSMZ
HeLa Cervical epithelial adenocarcinoma cell line Scherer et al., J Exp Med 97: 695 (1953) cervix F 31 DSMZ
MCF-7 Metastatic breast adenocarcinoma cell line Soule et al., J Natl Cancer Inst 51: 1409 (1973) pleural effusion F 69 DSMZ
SiHa Cervical squamous cell carcinoma cell line, integrated 1-2 copies of HPV16 Friedl F. et al.Proc., Soc. Exp. Biol. Med. 135: 543-545 (1970) cervix F 55 LGC/ATCC
SK-BR-3 Metastatic breast adenocarcinoma cell line Fogh J, editor. Human tumor cells in vitro. New York: Plenum Press (1975) pleural effusion F 43 LGC/ATCC
 
Urinary, male reproductive system
Cell line Description of cell line Original reference Origin Sex Age Source
NTERA-2 Metastatic embryonal carcinoma cell line, cloned from TERA-2 Fogh & Trempe, Human Tumor Cells in Vitro : 115 (1975)   M 22 DSMZ
PC-3 Metastatic poorly differentiated prostate adenocarcinoma cell line Kaighn et al., Invest Urol 17: 16-23 (1979) bone marrow M 62 DSMZ
RT-4 Urinary bladder transitional cell carcinoma cell line Rigby et al., Br J Cancer 24: 746 (1970) urinary bladder M 63 DSMZ
 
Skin
Cell line Description of cell line Original reference Origin Sex Age Source
A-431 Epidermoid carcinoma cell line Giard et al., J Natl Cancer Inst 51: 1417 (1973) skin F 85 DSMZ
HaCaT Keratinocyte cell line Boukamp et al., J Cell Biol Mar 106(3): 761 (1988) skin M 0 NEF3
SK-MEL-30 Metastatic malignant melanoma cell line Carey et al., Proc Natl Acad Sci USA 73: 3278 (1976) subcutis M 67 DSMZ
WM-115 Malignant melanoma cell line Westermark B. et al, Proc Natl Acad Sci U S A. Oct; 83(19): 7197 (1986) skin F 58 BW2
 
Sarcoma
Cell line Description of cell line Original reference Origin Sex Age Source
RH-30 Metastatic rhabdomyosarcoma cell line Douglass et al., Cytogenet Cell Genet 45: 148-155 (1987) bone marrow M 17 DSMZ
U-2 OS Osteosarcoma cell line Ponten J., Saksela E. Int. J. Cancer 2: 434 (1967) bone F 15 LGC/ATCC
U-2197 Malignant fibrous histiocytoma cell line Genberg et al., Am J Pathol 135: 1185 (1989) subcutis M 79 DSMZ
 
Miscellaneous
Cell line Description of cell line Original reference Origin Sex Age Source
BEWO Metastatic choriocarcinoma cell line Pattillo et al., Cancer Res 28: 1231-1236 (1968) brain   0 DSMZ
HEK 293 Embryonal kidney cell line, transformed by adenovirus type 5 Graham et al., J Gen Virol 36: 59 (1977) embryonal kidney   0 DSMZ
HTh 83 Anaplastic thyroid carcinoma cell line Dahlman et al., J. Pathol. 191: 376-386, 2000 thyroid M 67 NEH4
TIME Telomerase-immortalized human microvascular endothelial cells (pooled) Venetsanakos et el., Exp Cell Res., Feb 1;273(1): 21-33 (2002) skin   0 LCW5
 
Cells
Cell Description of origin Sex
Leukemia, AML   F
Leukemia, AML   F
Leukemia, B-ALL   F
Leukemia, B-CLL subtype 1 B-CLL subtype 1 (100) M
Leukemia, B-CLL subtype 2 B-CLL subtype 2 (95-98) M
Leukemia, B-CLL subtype 3 B-CLL subtype 3 (<95) F
Leukemia, B-CLL subtype 4 B-CLL subtype 4 (3-21) M
Leukemia, CML   M
Leukemia, CML   M
Leukemia, T-ALL   M
PBMC Peripheral Blood Mononuclear Cells from healthy blood donors M
PBMC Peripheral Blood Mononuclear Cells from healthy blood donors F

* Due to misidentification, KM3 has been omitted from the DSMZ catalogue and is now listed as "false leukemia cell line"
(www.dsmz.de/human_and_animal_cell_lines/main.php?content_id=97#False)
Drexler et al., False leukemia-lymphoma cell lines: An update on over 500 cell lines. Leukemia 17: 416-426 (2003)

** U87MG supplied by LGC/ATCC differs from the originally established U87MG described in the original reference.
Ponten J., Macintyre EH., Acta Pathol. Microbiol. Scand. 74: 465-486 (1968)

Source information
DSMZ, German Resource Centre for Biological Material (www.dsmz.de)
ATCC, American Type Culture Collection (www.lgcpromochem-atcc.com)
1 Prof. Kenneth Nilsson, Uppsala University, Uppsala, Sweden
2 Prof. Bengt Westermark, Uppsala University, Uppsala, Sweden
3 Prof. Norbert E Fusenig, DKFZ, Heidelberg, Germany
4 Assoc. Prof. Nis-Erik Heldin, Uppsala University, Uppsala, Sweden
5 Prof. Martin McMahon, UCSF Comprehensive Cancer Center, San Fransisco, USA

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