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Program description
The Human Protein Atlas (HPA) portal is a publicly available database with millions of high-resolution images showing the spatial distribution of proteins in 48 different normal tissues and 20 different cancer types as well as 47 different human cell lines. The antibodies are released together with application-specific validation performed for each antibody, including immunohistochemisty, Western blot analysis and, for a large fraction, a protein array assay and immunofluorescent based confocal microscopy. The database has been developed in a gene-centric manner with the inclusion of all human genes predicted from genome efforts together with a visualization of each protein with characteristics such as predicted membrane regions, signal peptide and protein domains and plots showing the uniqueness (sequence similarity) of every fraction of each protein towards all other human proteins. Search functionalities allow for complex queries regarding protein expression profiles, protein classes and chromosome location.

Berglund et al (2008). A gene-centric human protein atlas for expression profiles based on antibodies. Mol Cell Proteomics. 7(10):2019-27

Uhlén et al (2005). A Human Protein Atlas for Normal and Cancer Tissues Based on Antibody Proteomics. Mol Cell Proteomics. 4(12):1920-1932

Nilsson et al (2005). Towards a human proteome atlas: High-throughput generation of mono-specific antibodies for tissue profiling. Proteomics. 5(17):4327-37

Pontén F et al (2008). The Human Protein Atlas - a tool for pathology. J Pathology. 216(4):387-93.




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