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| Gene name: |
| KDELR1 (HGNC (automatic)) |
Synonyms: ERD2, ERD2.1, HDEL |
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| Description: |
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
Source acc: 6304 (HGNC Symbol) |
| Chromosome: |
19 |
| Cytoband: |
q13.33 |
| Chromosome location (bp): |
48885827 - 48894810 |
| Number of splice variants: |
1 |
| EnsEMBL ID: |
ENSG00000105438 |
| EnsEMBL version: |
57.37 |
| Stanford source search: |
Search for "KDELR1" |
| NCBI gene ID: |
10945 |
| NCBI gene summary: |
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq] |
| Gene ontology: |
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Protein data - 1 matching of 1 transcript |
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| Protein EnsEMBL ID: |
ENSP00000329471 |
| Transcript EnsEMBL ID: |
ENST00000330720 |
| Transcript display name: |
KDELR1-201 |
| Uniprot ID: |
P24390 (EnsEMBL direct mapping) |
| Number of amino acids: |
212 |
| Molecular weight: |
25 kDa |
| Protein class: |
Potential transmembrane proteins Ma, Membrane proteins predicted by MDM Mb, MEMSAT3 predicted membrane proteins Md, MEMSAT-SVM predicted membrane proteins Me, Phobius predicted membrane proteins Mf, SCAMPI predicted membrane proteins Mg, SPOCTOPUS predicted membrane proteins Mh, THUMBUP predicted membrane proteins Mi, TMHMM predicted membrane proteins Mj, 7TM proteins predicted by MDM Mx |
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