Proteins detected in plasma using proximity extension assay

Proximity extension assays (PEA) based on Olink was performed for 748 proteins based on a longitudinal wellness study covering 86 individuals with four visits during one year at three months intervals. The results are presented as Normalized Protein Expression (NPX) for the individual genes corresponding to these proteins for all females and males respectively.

Below is a summary of the variation between individuals and within individuals for these 748 proteins calculated as the mean standard variation (SD) for each protein within each visit and across all analyzed individuals (n=86), and as the mean SD for each protein within each individual across all visits (n=4), respectively.

Gene Gene description Variation within individuals Variation between individuals
GH1 Growth hormone 1 2.04 0.98
FOLR3 Folate receptor 3 1.54 0.1
MICA MHC class I polypeptide-related sequence A 1.44 0.16
MICB MHC class I polypeptide-related sequence B 1.44 0.16
CGA Glycoprotein hormones, alpha polypeptide 1.2 0.23
GH2 Growth hormone 2 1.16 0.28
CCL20 C-C motif chemokine ligand 20 1.13 0.51
EPCAM Epithelial cell adhesion molecule 1.11 0.33
SERPINA12 Serpin family A member 12 1.1 0.32
PVALB Parvalbumin 1.1 0.39
HAO1 Hydroxyacid oxidase 1 1.1 0.55
LEP Leptin 1.09 0.3
MMP1 Matrix metallopeptidase 1 1.08 0.56
TCL1A T cell leukemia/lymphoma 1A 1.05 0.32
PPY Pancreatic polypeptide 1.01 0.28
FGF21 Fibroblast growth factor 21 0.97 0.55
IGFBP1 Insulin like growth factor binding protein 1 0.97 0.4
FCRLB Fc receptor like B 0.93 0.18
FGF19 Fibroblast growth factor 19 0.93 0.58
MEP1B Meprin A subunit beta 0.91 0.2
SSC4D Scavenger receptor cysteine rich family member with 4 domains 0.89 0.27
CD177 CD177 molecule 0.87 0.17
CCL17 C-C motif chemokine ligand 17 0.86 0.47
LHB Luteinizing hormone beta polypeptide 0.85 0.24
MBL2 Mannose binding lectin 2 0.85 0.16
CXCL10 C-X-C motif chemokine ligand 10 0.85 0.32
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Leptin example


Figure 1 Protein profiles of Leptin shown with the individual concentrations across four visits with three months interval and the median levels for males and females, respectively.

Figure 2 A summary of the results for females and males as "violin" plots showing the distribution of protein levels of Leptin across the individuals for each visit. These plots are shown for all the 748 proteins on respective gene page accessed though the links in the Table above.