Mouse Pons and Medulla oblongata
Regionally elevated expression in mouse
Figure 2. Schematic drawing of the mouse brain, indicating the location of pons and medulla from a sagittal view.
The transcriptome analysis shows that 62% (n=12587) of all mouse one-to-one human orthologue genes (n=16679) are expressed in the pons and medulla and 98 genes show an elevated expression in pons and medulla compared to other regions of the brain.
Table 3: Number of genes within the different categories of regionally elevated expression, in mouse pons and medulla
Elevated expression in pons and medulla compared to other brain regions is divided into three different categories; regionally enriched (at least four-fold higher mRNA levels in pons and medulla compared to all other regions), group enriched (at least four-fold higher mRNA levels in a group of 2-5 regions) and regionally enhanced (at least four-fold higher mRNA levels in pons and medulla compared to the average of all regions), The number of genes in the individual category is shown in Table 3. In Table 4, the 12 genes with the highest level of regional specificity among the 37 enriched genes are listed.
Table 4: The 12 genes with the highest level of enriched expression in mouse pons and medulla. "Predicted localization" shows the classification of each gene into three main classes: Secreted, Membrane, and Intracellular, where the latter consists of genes without any predicted membrane and secreted features. RS-score (Regional Specificity score) corresponds to the score calculated as the fold change to the second highest region.