Normal colon showing ACTA2 (also named smooth muscle actin, SMA) expression in the smooth muscle cells that constitute the deep muscular wall of colon. ACTA2 expression is also found in smooth muscle cells of the lamina muscularis mucosae and in blood vessel walls that contain smooth muscle cells.
ACTA2 - Smooth muscle marker
The ACTA2 gene encodes for alpha smooth muscle actin (SMA, ASMA), a member of the actin family of proteins. SMA is expressed in smooth muscle cells, myofibroblasts and myoepithelial cells. In clinical immunohistochemistry, SMA antibodies can be useful to visualize smooth muscle cells in vascular walls, gut tissue, uterus etc. and to detect myoepithelial cells in breast for distinguishing invasive breast cancer from benign sclerosing lesions and ductal carcinoma in situ (DCIS). Alpha smooth muscle actin antibodies are also used in research to identify cancer associated fibroblasts (CAF) in the stroma that surrounds cancer cells.
in the protein atlas.