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Dictionary > Protein expression > MKI67

Detail 1
Normal colon showing expression of the proliferation marker Ki-67 (MKI67) in the nuclei of proliferating glandular cells. Ki-67 expression is mainly found in deeper parts of colonic crypts. Ki-67 expression is additionally seen in a few inflammatory cells present in lamina propria.

Ki-67 (MKI67) - General marker for proliferation

The MKI67 gene encodes a widely known yet functionally poorly characterized protein called Ki-67 that specifically labels the nuclei and chromosomes of cells actively undergoing proliferation, but is not detected in cells that are in resting G0-phase. Thus, Ki-67 is a very general marker for actively proliferating cells and this characteristic has been heavily exploited in both research and clinical work. It is commonly used to assess the proliferative activity in tumors, which may be a measure of aggressiveness in certain types of cancer.

Show MKI67 in the protein atlas.

Normal tissue - Protein expression

Lymph node
Urinary bladder

Cancer tissue - Protein expression

Breast cancer 1, ductal carcinoma
Breast cancer 2, ductal carcinoma
Carcinoid 1
Carcinoid 2
Colorectal cancer 1, adenocarcinoma
Colorectal cancer 2, adenocarcinoma
Colorectal cancer 3, adenocarcinoma
Lung cancer 1, adenocarcinoma
Lung cancer 2, squamous cell carcinoma
Lung cancer 3, small cell lung carcinoma
Lung cancer 4, adenocarcinoma
Lymphoma 1, B-CLL
Lymphoma 2, Hodgkin lymphoma
Lymphoma 3, follicular lymphoma
Lymphoma 4, DLBCL
Lymphoma 5, Hodgkin lymphoma
Melanoma 1
Melanoma 2
Prostate cancer 1, adenocarcinoma
Prostate cancer 2, adenocarcinoma
Prostate cancer 3, adenocarcinoma
Testis cancer 1, seminoma
Testis cancer 2, mixed germinal cell tumor
Thyroid cancer 1, follicular carcinoma
Thyroid cancer 2, papillary carcinoma