Protein expression - TP63


High magnification of prostate cancer (adenocarcinoma) showing expression of the basal cell marker p63 (TP63). Nuclear staining of p63 is seen in the basal cells of normal ducts. Tumor cells are negative.

p63 (TP63) - Marker for basal epithelial cells

The TP63 gene encodes the p63 protein, a transcription factor expressed in a number of developing and normal human tissues. p63 is widely used as a marker for basal cells in various epithelia, as well as a marker for cancers derived from squamous epithelia. It is also clinically used in diagnostics regarding prostate cancer, to distinguish benign glands (which have p63-positive basal cells) from prostate cancer, which lack p63 expression.
Show TP63 in the protein atlas.