Previously we have highlighted proteins expressed in the human neural retina. This week's article emphasizes the cellular structure and molecular dynamics of the lens.
The main function of the lens is to focus light on the retina. The passage of light through the cornea, lens and vitreous all the way to the retinal layer of the eye is only possible due to transparency of the tissue. Although the lens is very protein-rich, light absorption and light scattering in the lens is minimal.
The lens comprises non-diving lens cells which are mainly composed of ordered proteins called crystallins...Read more
Mathias Uhlen from the Human Protein Atlas will on July the 27 present a keynote lecture on the Europe-Korea Conference on Science and Technology (EKC2017) entitled "The Human Protein Atlas - implications for human biology, drug development and precision medicine"...Read more
TPX2 was identified in 1997 as a 100 kDa nuclear protein. In cells TPX2, a is a microtubule nucleation factor that translocates from the nucleus - where it resides during interphase - to the mitotic spindle during mitosis.
The mitotic spindle forms when chromosomes are ready to segregate during cell division and not surprisingly this protein is also found in this specific compartment of the cell! TPX2 is required for the correct formation of the kinetochores that is crucial for the attachment of microtubules, enabling the sister chromatids to be pulled apart. Due to its function TPX2 expression is cell-cycle dependent...Read more