Antibody validation by gene editing

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A podcast from Science hosted by the editor Sean Sanders was published on August 1st on the topic of antibody validation and the use of gene editing for genetic validation of research antibodies. The podcast from Science Custom Solutions! is part of a three-part series called "Changing bioscience research using CRISPR-edited cell models" in which bioscientists across a range of research fields are discussing how they are applying and adapting the latest technologies – in particular the most recent advances in CRISPR-based gene editing – to their area of study.

The first of the three interviewees is Dr. Robin Ketteler from the Laboratory for Molecular Cell Biology Group Leader and High Content Biology Leader at University College London in the United Kingdom. Robin is an expert in cell signaling and autophagy.

Next is Dr. Stephen Jackson, professor in the Department of Biochemistry at the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge. He studies DNA damage and repair.

The third interview published is Dr. Mathias Uhlén from KTH Royal Institute of Technology and Karolinska Institutet in Stockholm, Sweden. His broad focus is protein science and antibody engineering, but this time Mathias talks specifically about antibody validation.

Link to the interview