Intermediate filaments are part of a dynamic protein network, called the cytoskeleton, that provides shape, structural organization and mechanical resilience to human cells and tissues. Indeed, intermediate filaments have been proven to be very strong, while at the same time remaining flexible and elastic (Kreplak et al, 2005). Remarkably, they seem to stiffen when subjected to high mechanical force (Janmey et al, 1991), making them important contributors to integrity of cells, especially in tissues subjected to pronounced mechanical stress, such as our skin...Read more
A new Blood Atlas - a resource for exploration of blood cells and proteins - has been launched, as part of the open access Human Protein Atlas, in which the proteins in human blood cell types are described together with a comprehensive analysis of all proteins predicted to be secreted from human cells ("the secretome"). The new atlas provides a unique resource for the study of human biology and diseases, in particular for immune-based research and efforts to develop new, effective treatments in oncology and autoimmune diseases...Read more
A new Metabolic Atlas has been launched as part of the open access Human Protein Atlas program, allowing researchers to explore the expression of biochemical pathways across human tissues. The new resource leverages the most extensive mapping of human metabolism to date, with biochemical information and connectivity for more than 13,000 reactions, 4,000 unique compounds, and 3,500 genes...Read more
A new Brain Atlas is launched showing for the first time an integrated view of the proteins located to the different regions of the human, mouse and pig brain. The regional expression in these three mammalian brains have been profiled and the analysis includes 1,710 human brain samples, 119 pig brain samples and 67 mouse brain samples. The new database provides many insights of biological relevance for the human brain biology and disease...Read more
September 22, 2019 - September 26, 2019
Mathias Uhlen holds the PEACe keynote lecture, titled "The Human Secretome Project - generation of all human secreted proteins in mammalian cell cultures".
September 5, 2019